PMID- 9639428
OWN - NLM
STAT- MEDLINE
DCOM- 19980701
LR  - 20190914
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 12
IP  - 6
DP  - 1998 Jun
TI  - Abnormalities of the short arm of chromosome 12 in T cell prolymphocytic 
      leukemia.
PG  - 972-5
AB  - Abnormalities of the short arm of chromosome 12 are nonrandom events in T cell 
      prolymphocytic leukemia (T-PLL). Fluorescence in situ hybridization (FISH) 
      studies were performed in three patients with T-PLL and one patient with T cell 
      peripheral lymphoma and rearrangement of 12p. Whereas the rearrangements of 12p 
      were different in the four patients, a breakpoint centromeric to the ETV6 gene 
      was present in the three T-PLL patients. In addition, loss of heterozygosity for 
      a chromosomal segment telomeric to ETV6 with loss of the RAD52 locus was also 
      shown by FISH studies. In contrast, the breakpoint was telomeric to ETV6 in the 
      patient with peripheral lymphoma.
FAU - Salomon-Nguyen, F
AU  - Salomon-Nguyen F
AD  - INSERM U 301 and SD401 No. 301 CNRS, Paris, France.
FAU - Brizard, F
AU  - Brizard F
FAU - Le Coniat, M
AU  - Le Coniat M
FAU - Radford, I
AU  - Radford I
FAU - Berger, R
AU  - Berger R
FAU - Brizard, A
AU  - Brizard A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA-Binding Proteins)
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 12
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Prolymphocytic/*genetics
MH  - Leukemia, T-Cell/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1998/06/25 00:00
MHDA- 1998/06/25 00:01
CRDT- 1998/06/25 00:00
PHST- 1998/06/25 00:00 [pubmed]
PHST- 1998/06/25 00:01 [medline]
PHST- 1998/06/25 00:00 [entrez]
AID - 10.1038/sj.leu.2401034 [doi]
PST - ppublish
SO  - Leukemia. 1998 Jun;12(6):972-5. doi: 10.1038/sj.leu.2401034.