PMID- 9639761
OWN - NLM
STAT- MEDLINE
DCOM- 19980722
LR  - 20061115
IS  - 0529-567X (Print)
IS  - 0529-567X (Linking)
VI  - 32
IP  - 11
DP  - 1997 Nov
TI  - [Rapid prenatal diagnosis of Down's syndrome in the first trimester of pregnancy 
      by fluorescence in situ hybridization].
PG  - 646-8
AB  - OBJECTIVE: To assess whether fluorescence in situ hybridization (FISH) with 
      chromosome 21, specific DNA probe is applicable as a prenatal diagnostic tool for 
      Down's syndrome. METHOD: We used FISH with chromosome 21 specific probe on 30 
      uncultured chorionic villi cell samples to detect the Down's fetus, and we also 
      performed the conventional chromosome analysis of chorion cells from parallel 
      samples. RESULTS: In samples with disomic karyotype, an average of 1 percent (0-5 
      percent) of the nuclei had three hybridization signals. By contrast, in the 
      samples of trisomy 21 fetus, an average of 86 percent (78-91 percent) of the 
      nuclei displayed three signals. CONCLUSION: FISH can provide a rapid and accurate 
      method for the first trimester prenatal diagnosis of Down's syndrome.
FAU - Xiang, Y
AU  - Xiang Y
AD  - Peking Union Hospital, Peking Union Medical College, Chinese Academy of Medical 
      Science, Beijing.
FAU - Sun, N
AU  - Sun N
FAU - Wang, F
AU  - Wang F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Fu Chan Ke Za Zhi
JT  - Zhonghua fu chan ke za zhi
JID - 16210370R
SB  - IM
MH  - Chorionic Villi Sampling
MH  - Chromosomes, Human, Pair 21
MH  - Down Syndrome/*diagnosis/genetics
MH  - Female
MH  - Fetal Diseases/*diagnosis/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy, High-Risk
MH  - Prenatal Diagnosis/*methods
EDAT- 1998/06/26 00:00
MHDA- 1998/06/26 00:01
CRDT- 1998/06/26 00:00
PHST- 1998/06/26 00:00 [pubmed]
PHST- 1998/06/26 00:01 [medline]
PHST- 1998/06/26 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Fu Chan Ke Za Zhi. 1997 Nov;32(11):646-8.