PMID- 9640239
OWN - NLM
STAT- MEDLINE
DCOM- 19980707
LR  - 20190512
IS  - 0019-2805 (Print)
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Linking)
VI  - 93
IP  - 3
DP  - 1998 Mar
TI  - Inhibition of an established allergic response to ovalbumin in BALB/c mice by 
      killed Mycobacterium vaccae.
PG  - 307-13
AB  - Allergic disorders are mediated by T lymphocytes secreting T helper 2 (Th2) 
      cytokines, interleukin-4 (IL-4) and interleukin-5 (IL-5), resulting in high 
      levels of serum immunoglobulin E (IgE) and recruitment of eosinophils. One of the 
      treatment strategies is to downregulate the Th2 component by inducing a T helper 
      1 (Th1) response to the relevant allergen, because Th1 and Th2 cytokines are 
      thought to be mutually antagonistic. In this study, we examined the effects of 
      Mycobacterium vaccae, a potent inducer of Th1 immunity, on allergic responses in 
      a murine model. A single injection of M. vaccae into ovalbumin (OVA)-preimmunized 
      BALB/c mice suppressed serum IgE over a wide dose range (10(7), 10(8) or 10(9) M. 
      vaccae). Further experiments, using 10(7) M. vaccae injected twice, showed that 
      this treatment inhibited not only serum IgE, but also the potential for 
      ovalbumin-induced IL-5 production by spleen cells. This non-specific ability of a 
      mycobacterium to decrease Th2 activity, even when not presented together with the 
      allergen, is in agreement with recent epidemiological studies on the impact of 
      bacillus Calmette-Guerin (BCG) vaccination, and of other potent Th1 stimuli, on 
      the incidence of atopy. The suppression of serum IgE and allergen-specific IL-5 
      synthesis by M. vaccae suggest that this organism is likely to have clinical 
      application in the immunotherapy of allergy.
FAU - Wang, C C
AU  - Wang CC
AD  - Department of Bacteriology, UCL Medical School, London, UK.
FAU - Rook, G A
AU  - Rook GA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-5)
RN  - 0 (Vaccines, Inactivated)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Immunologic
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hypersensitivity/immunology/*prevention & control
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-2/biosynthesis
MH  - Interleukin-5/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mycobacterium/*immunology
MH  - Ovalbumin/immunology
MH  - Spleen/immunology
MH  - Th1 Cells/*immunology
MH  - Th2 Cells/*immunology
MH  - Vaccines, Inactivated
PMC - PMC1364077
EDAT- 1998/06/26 00:00
MHDA- 1998/06/26 00:01
PMCR- 1999/03/01
CRDT- 1998/06/26 00:00
PHST- 1998/06/26 00:00 [pubmed]
PHST- 1998/06/26 00:01 [medline]
PHST- 1998/06/26 00:00 [entrez]
PHST- 1999/03/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2567.1998.00432.x [doi]
PST - ppublish
SO  - Immunology. 1998 Mar;93(3):307-13. doi: 10.1046/j.1365-2567.1998.00432.x.