PMID- 9641137
OWN - NLM
STAT- MEDLINE
DCOM- 19980708
LR  - 20071114
IS  - 0099-2399 (Print)
IS  - 0099-2399 (Linking)
VI  - 24
IP  - 2
DP  - 1998 Feb
TI  - Endodontic pathogens stimulate monocyte chemoattractant protein-1 and 
      interleukin-8 in mononuclear cells.
PG  - 86-90
AB  - Microbial infection of the dental pulp leads to the recruitment of leukocytes and 
      the formation of lesions of endodontic origin. The chemokines interleukin-8 
      (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are relatively specific 
      chemoattractants for neutrophils and monocytes, respectively. In the present 
      studies, peripheral blood mononuclear cells were stimulated by Streptococcus 
      mutants, Porphyromonas endodontalis, and Peptostreptococcus anaerobius, which are 
      associated with lesions of endodontic origin. Each of these bacteria induced a 
      dose-dependent increase in IL-8 and MCP-1, determined by ELISA. The levels 
      induced are physiologically relevant. However, low doses of P. endodontalis were 
      less effective in inducing IL-8 or MCP-1 expression, compared with S. mutants or 
      P. anaerobius. Thus, these bacteria can induce significant levels of the 
      chemokines IL-8 and MCP-1, which could contribute to the recruitment of 
      neutrophils or monocytes in vivo. The expression of these mediators may 
      contribute to the development of endodontic infections, particularly with regard 
      to inflammatory leukocyte recruitment.
FAU - Jiang, Y
AU  - Jiang Y
AD  - Department of Endodontics, School of Dental Medicine, Boston University, MA, USA.
FAU - Russell, T R
AU  - Russell TR
FAU - Schilder, H
AU  - Schilder H
FAU - Graves, D T
AU  - Graves DT
LA  - eng
GR  - DE05642/DE/NIDCR NIH HHS/United States
GR  - DE07559/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Endod
JT  - Journal of endodontics
JID - 7511484
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-8)
MH  - Animals
MH  - Cells, Cultured
MH  - Chemokine CCL2/*biosynthesis
MH  - Dose-Response Relationship, Immunologic
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Interleukin-8/*biosynthesis
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Neutrophil Activation
MH  - Peptostreptococcus/immunology/physiology
MH  - Porphyromonas/immunology/*physiology
MH  - Rabbits
MH  - Streptococcus mutans/immunology/*physiology
EDAT- 1998/06/26 00:00
MHDA- 1998/06/26 00:01
CRDT- 1998/06/26 00:00
PHST- 1998/06/26 00:00 [pubmed]
PHST- 1998/06/26 00:01 [medline]
PHST- 1998/06/26 00:00 [entrez]
AID - S0099-2399(98)80083-6 [pii]
AID - 10.1016/S0099-2399(98)80083-6 [doi]
PST - ppublish
SO  - J Endod. 1998 Feb;24(2):86-90. doi: 10.1016/S0099-2399(98)80083-6.