PMID- 9642216
OWN - NLM
STAT- MEDLINE
DCOM- 19980806
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 273
IP  - 27
DP  - 1998 Jul 3
TI  - Steroid receptor coactivator-1 coactivates activating protein-1-mediated 
      transactivations through interaction with the c-Jun and c-Fos subunits.
PG  - 16651-4
AB  - Steroid receptor coactivator-1 (SRC-1) specifically bound to the transcription 
      factor AP-1 subunits c-Jun and c-Fos, as demonstrated by the yeast two-hybrid 
      tests and glutathione S-transferase pull down assays. The c-Jun and c-Fos binding 
      sites were localized to the C-terminal subregion of SRC-1 (amino acids 1101-1441) 
      that encompasses the previously described histone acetyltransferase and 
      receptor-binding domains. In mammalian cells, SRC-1, similar to the previous 
      results with CBP-p300 (Arias, J., Alberts, A. S., Brindle, P., Claret, F. X., 
      Smeal, T., Karin, M., Feramisco, J., and Montminy, M. (1994) Nature 370, 226-229; 
      Bannister, A. J., and Kouzarides, T. (1995) EMBO J. 14, 4758-4762), potentiated 
      the AP-1-mediated transactivations in a dose-dependent manner and derepressed the 
      mutual inhibitions between nuclear receptors and AP-1. Furthermore, coexpression 
      of p300 further enhanced this SRC-1-potentiated level of transactivations. Thus, 
      we concluded that at least two distinct coactivator molecules may cooperate to 
      regulate AP-1-dependent transactivations and mediate transrepression between AP-1 
      and nuclear receptors in vivo.
FAU - Lee, S K
AU  - Lee SK
AD  - College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
FAU - Kim, H J
AU  - Kim HJ
FAU - Na, S Y
AU  - Na SY
FAU - Kim, T S
AU  - Kim TS
FAU - Choi, H S
AU  - Choi HS
FAU - Im, S Y
AU  - Im SY
FAU - Lee, J W
AU  - Lee JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Transcription Factor AP-1)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (Nuclear Receptor Coactivator 1)
RN  - EC 2.3.1.48 (p300-CBP Transcription Factors)
RN  - EC 2.3.1.48 (p300-CBP-associated factor)
SB  - IM
MH  - Acetyltransferases/metabolism
MH  - Cell Cycle Proteins/metabolism
MH  - Cell Line
MH  - Histone Acetyltransferases
MH  - Nuclear Receptor Coactivator 1
MH  - Protein Binding
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Receptors, Cytoplasmic and Nuclear/metabolism
MH  - Transcription Factor AP-1/*metabolism
MH  - Transcription Factors/genetics/*metabolism
MH  - *Transcriptional Activation
MH  - Transfection
MH  - p300-CBP Transcription Factors
EDAT- 1998/06/27 00:00
MHDA- 1998/06/27 00:01
CRDT- 1998/06/27 00:00
PHST- 1998/06/27 00:00 [pubmed]
PHST- 1998/06/27 00:01 [medline]
PHST- 1998/06/27 00:00 [entrez]
AID - S0021-9258(18)80590-7 [pii]
AID - 10.1074/jbc.273.27.16651 [doi]
PST - ppublish
SO  - J Biol Chem. 1998 Jul 3;273(27):16651-4. doi: 10.1074/jbc.273.27.16651.