PMID- 9642305
OWN - NLM
STAT- MEDLINE
DCOM- 19980710
LR  - 20081121
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 110
IP  - 10
DP  - 1997 Oct
TI  - A study on rIL-4 and IFN-gamma regulating IgE synthesis in bronchial asthma 
      patients.
PG  - 760-3
AB  - OBJECTIVE: To investigate the cytokines responsible for pathophysiology of 
      asthma. METHODS: In vitro effects of recombinant interleukin-4 (rIL-4) and 
      interferon-gamma (IFN-gamma) on synthesis of immunoglobulin E (IgE) by peripheral 
      blood mononuclear cells (PBMC) were studied in 30 asthmatic patients and 25 
      normal controls. RESULTS: Spontaneous IgE synthesis by PBMC significantly 
      increased in patients with asthma compared with the controls (t = 4.471, P < 
      0.001). Although the maximum amounts of IgE synthesis using PBMC after 
      stimulation with rIL-4 were almost the same in the patients with asthma and in 
      the controls (P > 0.05), the enhancement rate of rIL-4-induced IgE synthesis was 
      lower in the asthma patients than in the controls (t = 4.6719, P > 0.005). 
      IFN-gamma suppressed both spontaneous and rIL-4-induced IgE synthesis by PBMC in 
      the asthma patients. The suppressive effect on IgE synthesis was more prominent 
      in the patients with asthma than in the controls (t = 7.1833, P < 0.001). 
      CONCLUSIONS: Asthma attacks are related to IgE-dependent trigger mechanism. The 
      imbalance of IL-4 and IFN-gamma in vivo is the cause of elevated IgE than can 
      produce mediators release and asthma attacks. IFN-gamma can inhibit IgE 
      synthesis, so IFN-gamma may be a new approach to the treatment of asthma.
FAU - Liu, X
AU  - Liu X
AD  - First Affiliated Hospital to Lanzhou Medical College, China.
FAU - Xing, Z
AU  - Xing Z
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Recombinant Proteins)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Asthma/*immunology
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis/blood
MH  - Interferon-gamma/*pharmacology
MH  - Interleukin-4/pharmacology
MH  - Leukocytes, Mononuclear/cytology
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/pharmacology
EDAT- 1998/06/27 00:00
MHDA- 1998/06/27 00:01
CRDT- 1998/06/27 00:00
PHST- 1998/06/27 00:00 [pubmed]
PHST- 1998/06/27 00:01 [medline]
PHST- 1998/06/27 00:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1997 Oct;110(10):760-3.