PMID- 9645793
OWN - NLM
STAT- MEDLINE
DCOM- 19980708
LR  - 20190512
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 147
IP  - 12
DP  - 1998 Jun 15
TI  - Gender differences in total and allergen-specific immunoglobulin E (IgE) 
      concentrations in a population-based cohort from birth to age four years.
PG  - 1145-52
AB  - While serum immunoglobulin E (IgE) concentration has been shown to be related to 
      allergic disease, there have been few studies of the natural history of IgE 
      development in young children. This study compared total and allergen-specific 
      serum IgE concentrations, by gender, from birth through 4 years of age using a 
      population-based cohort of normal children followed from 1987 to 1993. Subjects 
      were enrolled from a geographically defined area through membership in a large 
      health maintenance organization, and they resided in the northern suburbs of 
      Detroit, Michigan. Total IgE concentrations were measured at birth and at 2 and 4 
      years of age. Specific IgE concentrations to selected common inhalant allergens 
      (dust mite (Dematophagoides farinae), cat, ragweed (Ambrosia artemisiifolia), and 
      timothy grass (Pheleum pratense)) were measured at 2 and 4 years of age. Total 
      IgE increased with age from birth to 4 years for boys and girls, and was higher 
      in boys at 2 and 4 years of age. Girls demonstrated significant increases in IgE 
      to mite and cat and decreases in IgE to ragweed and timothy from 2 to 4 years of 
      age, whereas there was little change for boys except an increase in IgE to 
      ragweed. Differences in IgE development between young boys and girls may 
      partially account for the higher prevalence of asthma in boys than in girls.
FAU - Johnson, C C
AU  - Johnson CC
AD  - Division of Biostatistics and Research Epidemiology, Henry Ford Health System, 
      Detroit, MI, USA.
FAU - Peterson, E L
AU  - Peterson EL
FAU - Ownby, D R
AU  - Ownby DR
LA  - eng
GR  - AI24156/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Allergens/*immunology
MH  - Asthma/epidemiology/immunology
MH  - Child Development
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/analysis/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Sex Factors
EDAT- 1998/06/30 00:00
MHDA- 1998/06/30 00:01
CRDT- 1998/06/30 00:00
PHST- 1998/06/30 00:00 [pubmed]
PHST- 1998/06/30 00:01 [medline]
PHST- 1998/06/30 00:00 [entrez]
AID - 10.1093/oxfordjournals.aje.a009413 [doi]
PST - ppublish
SO  - Am J Epidemiol. 1998 Jun 15;147(12):1145-52. doi: 
      10.1093/oxfordjournals.aje.a009413.