PMID- 9648955
OWN - NLM
STAT- MEDLINE
DCOM- 19980901
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 11
IP  - 5
DP  - 1998 May
TI  - Atopy in cough sensitivity to capsaicin and bronchial responsiveness in young 
      females.
PG  - 1060-3
AB  - We have shown previously that female sex is a determinant of cough sensitivity to 
      inhaled capsaicin, but the relationship between atopy and the cough sensitivity 
      has not been examined. The capsaicin cough threshold, defined as the lowest 
      concentration of capsaicin causing five or more coughs, nonspecific bronchial 
      responsiveness, defined as the provocative concentration of methacholine causing 
      a 20% fall in the forced expiratory volume in one second (PC20), total 
      immunoglobulin E (IgE) and specific IgEs to eight common aeroallergens (house 
      dust 1, 2 and 6, Dermatophagoides pteronyssinus and D. farinae, Japanese cedar, 
      ragweed and orchard grass) in the serum were measured in 71 nonsmoking, healthy 
      young women aged 20.6+/-0.1 yrs (mean+/-EM). A structured interviewer-led 
      questionnaire on allergic diseases revealed that one and six subjects had mild 
      current and past asthma, respectively. These seven subjects were excluded from 
      the data analysis. PC20 was significantly lower in 42 subjects showing a positive 
      specific IgE than in 22 subjects showing a negative specific IgE to any of the 
      eight allergens (p<0.05), while the capsaicin cough threshold was not 
      significantly different between the subgroups. PC20 was significantly lower in 
      subjects with positive specific IgE to Dermatophagoides and house dust, but not 
      to the three kinds of pollen examined. It was confirmed that atopy indicated by 
      specific immunoglobulin E to mite-related antigens, but not to pollen antigens, 
      is associated with nonspecific bronchial responsiveness, and it is suggested that 
      atopy is not a determinant of airway cough sensitivity in healthy, nonasthmatic 
      subjects.
FAU - Fujimura, M
AU  - Fujimura M
AD  - Third Dept of Internal Medicine, Kanazawa University School of Medicine, Japan.
FAU - Kasahara, K
AU  - Kasahara K
FAU - Yasui, M
AU  - Yasui M
FAU - Myou, S
AU  - Myou S
FAU - Ishiura, Y
AU  - Ishiura Y
FAU - Kamio, Y
AU  - Kamio Y
FAU - Hashimoto, T
AU  - Hashimoto T
FAU - Matsuda, T
AU  - Matsuda T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Allergens)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Adult
MH  - Allergens/immunology
MH  - Bronchial Hyperreactivity/*etiology/physiopathology
MH  - Bronchoconstrictor Agents
MH  - *Capsaicin
MH  - Cough/*chemically induced
MH  - Cross-Sectional Studies
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Hypersensitivity/*complications/*physiopathology
MH  - Immunoglobulin E/analysis/immunology
MH  - Methacholine Chloride
MH  - Odds Ratio
MH  - *Sex Characteristics
EDAT- 1998/07/02 00:00
MHDA- 1998/07/02 00:01
CRDT- 1998/07/02 00:00
PHST- 1998/07/02 00:00 [pubmed]
PHST- 1998/07/02 00:01 [medline]
PHST- 1998/07/02 00:00 [entrez]
AID - 10.1183/09031936.98.11051060 [doi]
PST - ppublish
SO  - Eur Respir J. 1998 May;11(5):1060-3. doi: 10.1183/09031936.98.11051060.