PMID- 9650570
OWN - NLM
STAT- MEDLINE
DCOM- 19980709
LR  - 20191102
IS  - 1528-7394 (Print)
IS  - 0098-4108 (Linking)
VI  - 54
IP  - 5
DP  - 1998 Jul 10
TI  - Prevalence of respiratory symptoms and increased specific IgE levels in 
      West-African workers exposed to isocyanates.
PG  - 335-42
AB  - Respiratory symptoms and immunological effects from chronic exposure to 
      isocyanates (toluene diisocyanate) were studied in a cross survey of workers from 
      West African factories producing paints and polyurethane foam. A questionnaire, a 
      pulmonary function test, immunoglobulin E (IgE) levels, radioallergosorbent test 
      (RAST) and an atmospheric sample to quantify isocyanate exposures were carried 
      out in the workplace for each worker. Ninety-six workers, of whom 44 had 
      occupational isocyanate-induced asthma, were included in the study. Twenty-four 
      viral-infected subjects were excluded from the immunological study. Specific 
      antibodies to isocyanates were detected in two of the symptomatic individuals. 
      This low proportion appeared to be a common feature of this disease. The 
      prevalence of isocyanate-induced asthma in a West African working population 
      appears to be significant in the context of chronic human exposure, as current 
      data are based on excessive acute exposure due to an accident as seen in India.
FAU - Deschamps, F
AU  - Deschamps F
AD  - Department of Occupational Diseases, CHU Maison Blanche, Reims, France.
FAU - Sow, M L
AU  - Sow ML
FAU - Prevost, A
AU  - Prevost A
FAU - Henry, L
AU  - Henry L
FAU - Lavaud, F
AU  - Lavaud F
FAU - Bernard, J
AU  - Bernard J
FAU - Kochman, S
AU  - Kochman S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - J Toxicol Environ Health A
JT  - Journal of toxicology and environmental health. Part A
JID - 100960995
RN  - 0 (Isocyanates)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Africa, Western/epidemiology
MH  - *Chemical Industry
MH  - Chronic Disease
MH  - Humans
MH  - Immunoglobulin E/*metabolism
MH  - Isocyanates/*toxicity
MH  - Occupational Exposure/*adverse effects
MH  - Radioallergosorbent Test
MH  - Radioimmunoassay
MH  - Respiratory Function Tests
MH  - Respiratory Tract Diseases/*chemically induced/diagnosis/*epidemiology
MH  - Smoking/physiopathology
EDAT- 1998/07/03 00:00
MHDA- 1998/07/03 00:01
CRDT- 1998/07/03 00:00
PHST- 1998/07/03 00:00 [pubmed]
PHST- 1998/07/03 00:01 [medline]
PHST- 1998/07/03 00:00 [entrez]
AID - 10.1080/009841098158782 [doi]
PST - ppublish
SO  - J Toxicol Environ Health A. 1998 Jul 10;54(5):335-42. doi: 
      10.1080/009841098158782.