PMID- 9650697
OWN - NLM
STAT- MEDLINE
DCOM- 19980908
LR  - 20190905
IS  - 0193-1091 (Print)
IS  - 0193-1091 (Linking)
VI  - 20
IP  - 3
DP  - 1998 Jun
TI  - Detection of Epstein-Barr virus and HTLV-I in T-cell lymphomas of skin in Taiwan.
PG  - 250-4
AB  - Viral etiology has been associated with the pathogenesis of T-cell lymphomas of 
      skin (TCLS). Therefore, we studied the presence of Epstein-Barr virus (EBV) and 
      type I human T-cell lymphotropic virus (HTLV-I) in tumor cells of TCLS to 
      determine the significance of these viruses with the disease. A retrospective 
      study was conducted on the skin tissues from 28 Chinese patients with TCLS. We 
      used in situ hybridization, immunohistochemistry, and polymerase chain reaction 
      to determine the presence of viruses. Among the 28 cases, HTLV-I was only 
      detected in two cases with adult T-cell leukemia/lymphoma, not in other cases of 
      TCLS. This suggests that HTLV-I may not play a significant role in the 
      oncogenesis of TCLS in Chinese patients. Conversely, EBV was detected in 12 cases 
      (42.9%), including the secondary TCLS, large cell lymphoma, mycosis fungoides, 
      adult T-cell leukemia/lymphoma, and angiocentric lymphoma. Nevertheless, latent 
      membrane protein 1 was not detected in any of the EBV-positive cases. Neither was 
      any correlation found between the presence of EBV in TCLS and the prognosis or 
      the severity of the skin lesion. Although there is a close association of EBV 
      with a portion of TCLS, its pathogenic role needs further investigation.
FAU - Chang, Y T
AU  - Chang YT
AD  - Department of Dermatology, Veterans General Hospital-Taipei, National Yang-Ming 
      University, Taiwan.
FAU - Liu, H N
AU  - Liu HN
FAU - Chen, C L
AU  - Chen CL
FAU - Chow, K C
AU  - Chow KC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gene Expression/genetics
MH  - Herpesvirus 4, Human/*genetics
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Lymphoma, T-Cell/epidemiology/*virology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - RNA, Viral/analysis/genetics
MH  - Retrospective Studies
MH  - Skin/pathology/*virology
MH  - Skin Neoplasms/epidemiology/*virology
MH  - Taiwan/epidemiology
EDAT- 1998/07/03 00:00
MHDA- 1998/07/03 00:01
CRDT- 1998/07/03 00:00
PHST- 1998/07/03 00:00 [pubmed]
PHST- 1998/07/03 00:01 [medline]
PHST- 1998/07/03 00:00 [entrez]
AID - 10.1097/00000372-199806000-00005 [doi]
PST - ppublish
SO  - Am J Dermatopathol. 1998 Jun;20(3):250-4. doi: 10.1097/00000372-199806000-00005.