PMID- 9651531
OWN - NLM
STAT- MEDLINE
DCOM- 19980831
LR  - 20190707
IS  - 0378-1119 (Print)
IS  - 0378-1119 (Linking)
VI  - 214
IP  - 1-2
DP  - 1998 Jul 3
TI  - Genomic organization and cloning of the human homologue of murine Sipa-1.
PG  - 215-21
AB  - Murine Sipa-1 (signal-induced proliferation associated protein) is a mitogen 
      induced GTPase activating protein (GAP). While mapping candidate genes for 
      multiple endocrine neoplasia type 1 (MEN1) at 11q13, we cloned the human 
      homologue of Sipa-1. Herein, we report the complete cDNA sequence, expression, 
      and genomic organization of SIPA-1. SIPA-1 consists of 16 exons with highly 
      conserved exon-intron boundaries. The predicted SIPA-1 protein is highly 
      homologous to the mouse protein, particularly in the region of the GAP-related 
      domain at the amino terminus and the leucine zipper at the carboxy terminus. It 
      is widely expressed, including in fetal tissues, but is most highly expressed in 
      lymphoid organs. During the course of cloning SIPA-1, the MEN1 gene was 
      identified, thus excluding human SIPA-1 as a candidate for this disease.
FAU - Ebrahimi, S
AU  - Ebrahimi S
AD  - UCLA School of Medicine, West Los Angeles VA Medical Center Department of Surgery 
      Core Molecular Biology Unit, 10833 Le, Conte Ave. 72-215 CHS, Los Angeles, CA 
      90095-6904, USA.
FAU - Wang, E
AU  - Wang E
FAU - Udar, N
AU  - Udar N
FAU - Arnold, E
AU  - Arnold E
FAU - Burbee, D
AU  - Burbee D
FAU - Small, K
AU  - Small K
FAU - Sawicki, M P
AU  - Sawicki MP
LA  - eng
SI  - GENBANK/AF029789
SI  - GENBANK/AF052232
SI  - GENBANK/AF052233
SI  - GENBANK/AF052234
SI  - GENBANK/AF052235
SI  - GENBANK/AF052236
SI  - GENBANK/AF052237
SI  - GENBANK/AF052238
GR  - EY-02134/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (DNA, Complementary)
RN  - 0 (GTPase-Activating Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SIPA1 protein, human)
RN  - 0 (Sipa1 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Exons
MH  - Female
MH  - GTPase-Activating Proteins
MH  - Gene Expression
MH  - Humans
MH  - Introns
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Nuclear Proteins/*genetics
MH  - Proteins/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Species Specificity
MH  - Tissue Distribution
EDAT- 1998/07/04 00:00
MHDA- 1998/07/04 00:01
CRDT- 1998/07/04 00:00
PHST- 1998/07/04 00:00 [pubmed]
PHST- 1998/07/04 00:01 [medline]
PHST- 1998/07/04 00:00 [entrez]
AID - S0378-1119(98)00212-1 [pii]
AID - 10.1016/s0378-1119(98)00212-1 [doi]
PST - ppublish
SO  - Gene. 1998 Jul 3;214(1-2):215-21. doi: 10.1016/s0378-1119(98)00212-1.