PMID- 9654364
OWN - NLM
STAT- MEDLINE
DCOM- 19980817
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 248
IP  - 2
DP  - 1998 May 29
TI  - Central administration of urocortin inhibits vasopressin release in conscious 
      rats.
PG  - 144-6
AB  - Urocortin (UCN) is a new mammalian member of the corticotropin releasing factor 
      (CRF) family and supposed to be an endogenous ligand for type 2 CRF receptors. 
      Previous studies have revealed that UCN mRNA exists in the supraoptic nucleus 
      (SON), and that water deprivation increases UCN immunoreactivity in SON. In this 
      study, we examined the effect of centrally-administered UCN on arginine 
      vasopressin (AVP) release in conscious rats. Intracerebroventricular (i.c.v.) 
      injection of UCN (5.0 microg/rat) significantly attenuated AVP release induced by 
      hyperosmolality at 30 min after the injection. In contrast, CRF (5.0 microg/rat) 
      injected i.c.v. had no significant effect on AVP release. These results suggest 
      that central UCN play an inhibitory role in osmoregulation of AVP release.
FAU - Kakiya, S
AU  - Kakiya S
AD  - First Department of Internal Medicine, Nagoya University School of Medicine, 
      Japan.
FAU - Yokoi, H
AU  - Yokoi H
FAU - Arima, H
AU  - Arima H
FAU - Iwasaki, Y
AU  - Iwasaki Y
FAU - Oki, Y
AU  - Oki Y
FAU - Oiso, Y
AU  - Oiso Y
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Hypertonic Solutions)
RN  - 0 (Urocortins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Arginine Vasopressin/*blood
MH  - Corticotropin-Releasing Hormone/administration & dosage/*pharmacology
MH  - Hypertonic Solutions
MH  - Injections, Intraventricular
MH  - Male
MH  - Osmolar Concentration
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Urocortins
EDAT- 1998/07/08 00:00
MHDA- 1998/07/08 00:01
CRDT- 1998/07/08 00:00
PHST- 1998/07/08 00:00 [pubmed]
PHST- 1998/07/08 00:01 [medline]
PHST- 1998/07/08 00:00 [entrez]
AID - S0304-3940(98)00357-7 [pii]
AID - 10.1016/s0304-3940(98)00357-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 1998 May 29;248(2):144-6. doi: 10.1016/s0304-3940(98)00357-7.