PMID- 9655715
OWN - NLM
STAT- MEDLINE
DCOM- 19980730
LR  - 20221207
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 158
IP  - 1
DP  - 1998 Jul
TI  - Analysis of HLA-DPB1 polymorphisms in African-Americans with sarcoidosis.
PG  - 111-4
AB  - Several studies have found weak associations between certain human leukocyte 
      antigen (HLA) alleles and sarcoidosis, but none have been conclusive. Glutamic 
      acid at position 69 in HLA-DPB1 has been reported to be strongly associated with 
      chronic beryllium disease. The immunopathologic and clinical similarities between 
      chronic beryllium disease (CBD) and sarcoidosis suggest that similar 
      immune-response genes may be involved in susceptibility in both diseases. We 
      analyzed the DNA sequence of HLA-DPB1 exon 2, which contains the hypervariable 
      regions involved in binding antigens, in blood samples from African-American 
      sarcoidosis patients and healthy controls. Results indicate that Val36 (odds 
      ratio [OR] = 2.30) and Asp55 (OR = 2.03) are associated with increased risk for 
      sarcoidosis, but no association with Glu69 was found. These results suggest that 
      although HLA-DPB1 Glu69 is not associated with sarcoidosis, other alleles may 
      make some contribution to susceptibility to sarcoidosis in African-Americans.
FAU - Maliarik, M J
AU  - Maliarik MJ
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, and Department of Biostatistics and Research Epidemiology, Henry Ford 
      Health Sciences Center, Detroit, Michigan, USA.
FAU - Chen, K M
AU  - Chen KM
FAU - Major, M L
AU  - Major ML
FAU - Sheffer, R G
AU  - Sheffer RG
FAU - Popovich, J Jr
AU  - Popovich J Jr
FAU - Rybicki, B A
AU  - Rybicki BA
FAU - Iannuzzi, M C
AU  - Iannuzzi MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (HLA-DP Antigens)
RN  - 0 (Immunoglobulin Variable Region)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Black People/*genetics
MH  - Female
MH  - HLA-DP Antigens/*genetics
MH  - Humans
MH  - Immunoglobulin Variable Region
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymorphism, Genetic
MH  - Sarcoidosis, Pulmonary/ethnology/*genetics
MH  - Sequence Analysis, DNA
EDAT- 1998/07/09 02:03
MHDA- 2001/03/28 10:01
CRDT- 1998/07/09 02:03
PHST- 1998/07/09 02:03 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1998/07/09 02:03 [entrez]
AID - 10.1164/ajrccm.158.1.9708111 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1998 Jul;158(1):111-4. doi: 
      10.1164/ajrccm.158.1.9708111.