PMID- 9657147
OWN - NLM
STAT- MEDLINE
DCOM- 19980727
LR  - 20220227
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 93
IP  - 7
DP  - 1998 Jun 26
TI  - Developmental regulation of invariant chain proteolysis controls MHC class II 
      trafficking in mouse dendritic cells.
PG  - 1135-45
AB  - Dendritic cells (DCs) developmentally regulate their capacity for antigen 
      presentation by controlling the transport and surface expression of MHC class II 
      molecules. These events reflect a developmental regulation of invariant (Ii) 
      chain cleavage, most likely by the cysteine protease cathepsin S. In immature 
      DCs, inefficient Ii chain cleavage due to low cathepsin S activity leads to the 
      transport of class II-Ii chain complexes to lysosomes, while in mature DCs, 
      elevated cathepsin S activity results in efficient delivery of class II alphabeta 
      dimers to the plasma membrane. Cathepsin S is not controlled transcriptionally 
      but by a novel mechanism involving alterations in the expression and localization 
      of an endogenous cathepsin S inhibitor cystatin C. Thus, the ratio of cystatin C 
      to cathepsin S in developing DCs helps to determine the fate of newly synthesized 
      MHC class II molecules.
FAU - Pierre, P
AU  - Pierre P
AD  - Department of Cell Biology, Yale University School of Medicine, New Haven, 
      Connecticut 06520-8002, USA.
FAU - Mellman, I
AU  - Mellman I
LA  - eng
GR  - AI-34098/AI/NIAID NIH HHS/United States
GR  - GM-33904/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Cst3 protein, mouse)
RN  - 0 (Cystatin C)
RN  - 0 (Cystatins)
RN  - 0 (Cysteine Proteinase Inhibitors)
RN  - 0 (DNA, Complementary)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (invariant chain)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.22.27 (cathepsin S)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - Antigens, Differentiation, B-Lymphocyte/*metabolism
MH  - Biological Transport
MH  - Cathepsins/antagonists & inhibitors/metabolism
MH  - Cell Membrane/metabolism
MH  - Cystatin C
MH  - Cystatins/analysis/genetics
MH  - Cysteine Proteinase Inhibitors/analysis/genetics
MH  - DNA, Complementary
MH  - Dendritic Cells/*immunology
MH  - Dimerization
MH  - Enzyme Inhibitors/pharmacology
MH  - Histocompatibility Antigens Class II/*metabolism
MH  - Lysosomes/metabolism
MH  - Male
MH  - Mice
MH  - Transfection
EDAT- 1998/07/10 00:00
MHDA- 1998/07/10 00:01
CRDT- 1998/07/10 00:00
PHST- 1998/07/10 00:00 [pubmed]
PHST- 1998/07/10 00:01 [medline]
PHST- 1998/07/10 00:00 [entrez]
AID - S0092-8674(00)81458-0 [pii]
AID - 10.1016/s0092-8674(00)81458-0 [doi]
PST - ppublish
SO  - Cell. 1998 Jun 26;93(7):1135-45. doi: 10.1016/s0092-8674(00)81458-0.