PMID- 9657372
OWN - NLM
STAT- MEDLINE
DCOM- 19980723
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 429
IP  - 1
DP  - 1998 Jun 5
TI  - Mode of receptor binding and activation by plasminogen-related growth factors.
PG  - 1-3
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) and macrophage stimulating 
      protein (MSP) are plasminogen-related kringle proteins that lost serine protease 
      domain enzymatic activity and became ligands for cell surface tyrosine kinase 
      receptors. They are activated by cleavage to disulfide-linked alphabeta chains. 
      Surprisingly, despite structural similarities, the high affinity receptor binding 
      regions of the two proteins are different: alpha chain for HGF, and beta chain 
      for MSP. We propose that after cleavage exposes a beta chain binding site (high 
      affinity for MSP, low affinity for HGF), monomeric ligand induces receptor 
      dimerization and activation via alpha and beta chain binding sites of different 
      affinity.
FAU - Miller, M
AU  - Miller M
AD  - Macromolecular Structure Laboratory, NCI-Frederick Cancer Research and 
      Development Center, ABL-Basic Research Program, MD 21702-1201, USA.
FAU - Leonard, E J
AU  - Leonard EJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Dimerization
MH  - Hepatocyte Growth Factor/chemistry/*metabolism
MH  - Humans
MH  - Kringles/physiology
MH  - Macrophage Colony-Stimulating Factor/chemistry/metabolism
MH  - Models, Molecular
MH  - Proto-Oncogene Proteins c-met/metabolism
EDAT- 1998/07/10 00:00
MHDA- 1998/07/10 00:01
CRDT- 1998/07/10 00:00
PHST- 1998/07/10 00:00 [pubmed]
PHST- 1998/07/10 00:01 [medline]
PHST- 1998/07/10 00:00 [entrez]
AID - S0014-5793(98)00533-X [pii]
AID - 10.1016/s0014-5793(98)00533-x [doi]
PST - ppublish
SO  - FEBS Lett. 1998 Jun 5;429(1):1-3. doi: 10.1016/s0014-5793(98)00533-x.