PMID- 9657416
OWN - NLM
STAT- MEDLINE
DCOM- 19980818
LR  - 20190826
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 78
IP  - 3
DP  - 1998 May 8
TI  - HLA antigens in childhood onset schizophrenia.
PG  - 123-32
AB  - Evidence of immune system abnormalities in adult schizophrenia has prompted 
      examination of the human leukocyte antigen (HLA) system. Childhood onset 
      schizophrenia offers a unique opportunity to test neurodevelopmental hypotheses 
      of schizophrenia, including those which implicate components of the immune 
      system. In the present study, class I and II HLA antigens were typed using 
      sequence-specific primers and the polymerase chain reaction in 28 childhood onset 
      schizophrenics and 51 ethnically matched healthy subjects. Groups were compared 
      for frequencies of HLA antigens reported to be associated with schizophrenia 
      and/or autoimmune disorders. We hypothesized that antigen frequencies would 
      differ between schizophrenic and healthy children, suggesting that some dimension 
      of the neurodevelopmental disturbance experienced by these children may be 
      mediated by subtle abnormalities of immune function. There were no significant 
      differences between schizophrenic and healthy subjects in the frequency of any 
      antigen tested. These findings do not support HLA-associated pathology in 
      childhood onset schizophrenia.
FAU - Jacobsen, L K
AU  - Jacobsen LK
AD  - Yale University School of Medicine, Department of Psychiatry, Veterans Affairs 
      Connecticut Healthcare System, West Haven 06516, USA.
FAU - Mittleman, B B
AU  - Mittleman BB
FAU - Kumra, S
AU  - Kumra S
FAU - Lenane, M C
AU  - Lenane MC
FAU - Barracchini, K C
AU  - Barracchini KC
FAU - Adams, S
AU  - Adams S
FAU - Simonis, T
AU  - Simonis T
FAU - Lee, P R
AU  - Lee PR
FAU - Long, R T
AU  - Long RT
FAU - Sharp, W
AU  - Sharp W
FAU - Sidransky, E
AU  - Sidransky E
FAU - Ginns, E I
AU  - Ginns EI
FAU - Rapoport, J L
AU  - Rapoport JL
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - HLA Antigens/*immunology
MH  - HLA-A Antigens/immunology
MH  - HLA-B Antigens/immunology
MH  - HLA-D Antigens/immunology
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Schizophrenia, Childhood/*immunology
EDAT- 1998/07/10 00:00
MHDA- 1998/07/10 00:01
CRDT- 1998/07/10 00:00
PHST- 1998/07/10 00:00 [pubmed]
PHST- 1998/07/10 00:01 [medline]
PHST- 1998/07/10 00:00 [entrez]
AID - S0165178198000158 [pii]
AID - 10.1016/s0165-1781(98)00015-8 [doi]
PST - ppublish
SO  - Psychiatry Res. 1998 May 8;78(3):123-32. doi: 10.1016/s0165-1781(98)00015-8.