PMID- 9659567
OWN - NLM
STAT- MEDLINE
DCOM- 19980915
LR  - 20190607
IS  - 0835-7900 (Print)
IS  - 0835-7900 (Linking)
VI  - 12
IP  - 4
DP  - 1998 May-Jun
TI  - Inflammatory bowel disease with cytoplasmic-staining antineutrophil cytoplasmic 
      antibody and extensive colitis.
PG  - 279-82
AB  - A cohort of 18 patients with inflammatory bowel disease who were characterized by 
      the presence of cytoplasmic-staining antineutrophil cytoplasmic antibody (cANCA) 
      and extensive colitis is reported. Almost half were Indo-Canadians, and atypical 
      perinuclear-staining antineutrophil cytoplasmic antibody was also detected in 
      five (28%), similar to the detection rate for Crohn's disease and other less 
      commonly detected forms of colitis, such as lymphocytic or collagenous colitis. 
      Careful pathological review of all endoscopic biopsies and surgically resected 
      colonic tissues did not reveal evidence of vasculitis or so-called 'palisading' 
      granulomas, which is a typical pathological change of Wegener's granulomatosis, 
      an entity that has been traditionally characterized by the detection of cANCA. 
      This report describes 18 patients with extensive colitis and the seromarker cANCA 
      but without clinical features or histological evidence of vasculitis.
FAU - Freeman, H J
AU  - Freeman HJ
AD  - Department of Medicine (Gastroenterology), University of British Columbia, 
      Vancouver.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Canada
TA  - Can J Gastroenterol
JT  - Canadian journal of gastroenterology = Journal canadien de gastroenterologie
JID - 8807867
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Cohort Studies
MH  - Colonoscopy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fluorescent Antibody Technique, Indirect
MH  - Humans
MH  - Inflammatory Bowel Diseases/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 1998/07/11 00:00
MHDA- 1998/07/11 00:01
CRDT- 1998/07/11 00:00
PHST- 1998/07/11 00:00 [pubmed]
PHST- 1998/07/11 00:01 [medline]
PHST- 1998/07/11 00:00 [entrez]
AID - 10.1155/1998/186063 [doi]
PST - ppublish
SO  - Can J Gastroenterol. 1998 May-Jun;12(4):279-82. doi: 10.1155/1998/186063.