PMID- 9660264
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20190826
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 24
IP  - 5
DP  - 1998 May
TI  - A scoring system to predict the evolution of respiratory distress syndrome into 
      chronic lung disease in preterm infants.
PG  - 476-80
AB  - OBJECTIVE: The purpose of this study was to develop and validate an empirical 
      scoring system to predict the evolution of neonatal respiratory distress syndrome 
      (RDS) into chronic lung disease (CLD) in preterm infants, by comparing it with a 
      more complicated logistic regression model. DESIGN: Clinical study. SETTING: 
      Neonatal intensive care unit. PATIENTS: The retrospective analysis of a 3-year 
      experience showed that a gestational age (GA) of less than 30 weeks, a birth 
      weight (BW) of less than 1000 g, the diagnosis of hyaline membrane disease (HMD) 
      and pulmonary interstitial emphysema (PIE) during the first 72 h of life, the 
      peak inspiratory pressure (PIP) and the fraction of inspired oxygen (FIO2) were 
      the highest relative risk factors correlated with the evolution of CLD. On this 
      basis an empirical and a statistical scoring system were defined and 
      prospectively applied at 3 and 5 days of life to 228 neonates with BW less than 
      1,250 g. The results obtained with both scoring systems were then compared. 
      RESULTS: Of the 149 infants surviving at 28 days of life, 67 (GA: 29.9 +/- 2.3 
      weeks; BW: 1,058 +/- 143 g) were normal and 82 (GA: 27.5 +/- 3.9 weeks: BW: 838 
      +/- 200 g) had CLD. Using a cut-off value of 4.0, the empirical scoring system 
      showed a specificity of 97.0% and a sensitivity of 92.7% on the 3rd day of life; 
      on the 5th day of life the specificity was still 95.5%, while sensitivity 
      remained 92.7%. The areas under the ROC curves plotted with both scoring systems 
      tested were similar. CONCLUSIONS: The proposed empirical scoring system is easy 
      to use and is highly reliable. The application of this scoring system provides 
      the opportunity to direct aggressive treatment for CLD toward only very high risk 
      patients between the 3rd and 5th days of life.
FAU - Romagnoli, C
AU  - Romagnoli C
AD  - Division of Neonatology, Institute of Pediatrics, Catholic University of the 
      Sacred Heart, Rome, Italy.
FAU - Zecca, E
AU  - Zecca E
FAU - Tortorolo, L
AU  - Tortorolo L
FAU - Vento, G
AU  - Vento G
FAU - Tortorolo, G
AU  - Tortorolo G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
CIN - Intensive Care Med. 1999 Feb;25(2):241-2. PMID: 10193562
MH  - Chronic Disease
MH  - Disease Progression
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Infant, Premature, Diseases/*diagnosis
MH  - Logistic Models
MH  - Lung Diseases/*diagnosis
MH  - Prognosis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Respiratory Distress Syndrome, Newborn/*diagnosis
MH  - Retrospective Studies
MH  - Risk
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
EDAT- 1998/07/11 00:00
MHDA- 1998/07/11 00:01
CRDT- 1998/07/11 00:00
PHST- 1998/07/11 00:00 [pubmed]
PHST- 1998/07/11 00:01 [medline]
PHST- 1998/07/11 00:00 [entrez]
AID - 10.1007/s001340050599 [doi]
PST - ppublish
SO  - Intensive Care Med. 1998 May;24(5):476-80. doi: 10.1007/s001340050599.