PMID- 9663452
OWN - NLM
STAT- MEDLINE
DCOM- 19980928
LR  - 20190818
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 19
IP  - 5
DP  - 1998
TI  - Differential effects of intracerebroventricular glucagon-like peptide-1 on 
      feeding and energy expenditure regulation.
PG  - 869-75
AB  - Intracerebroventricular (i.c.v.) administration of glucagon-like peptide-1-(7-37) 
      amide (GLP-1) has been shown to modulate food and water intake. The present 
      studies further characterize the effects of i.c.v. GLP-1 in the regulation of 
      energy balance in lean and obese animals. In both obese and lean Zucker rats, a 
      single i.c.v. infusion of GLP-1 (1-30 microg) resulted in a dose-dependent 
      reduction of food intake and decrease in respiratory quotient relative to the 
      saline control during the first 2 h of the nocturnal cycle. In obese Zucker rats, 
      the food intake was reduced by 73 +/- 11% of the control at the 30 microg dose, 
      whereas a modest 45 +/- 18% reduction was observed in lean rats. Despite the 
      large reduction in food intake seen with GLP-1, there was no compensatory 
      decrease in nocturnal oxygen consumption in the obese Zucker rats. Interestingly, 
      low doses of GLP-1 (1 microg) in lean Zucker rats, which had minimal effects on 
      food intake, caused a 19 +/- 7% increase in O2 consumption during the first 2 h 
      of the nocturnal cycle. These data suggest that central GLP-1 may be an important 
      factor controlling negative energy balance in both the lean and obese Zucker 
      rats.
FAU - Hwa, J J
AU  - Hwa JJ
AD  - Department of CNS and Cardiovascular Research, Schering-Plough Research 
      Institute, Kenilworth, NJ 07033, USA. joyce.hwa@spcorp.com
FAU - Ghibaudi, L
AU  - Ghibaudi L
FAU - Williams, P
AU  - Williams P
FAU - Witten, M B
AU  - Witten MB
FAU - Tedesco, R
AU  - Tedesco R
FAU - Strader, C D
AU  - Strader CD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Drinking Behavior/*drug effects
MH  - Energy Metabolism/*drug effects
MH  - Feeding Behavior/*drug effects
MH  - Glucagon/*pharmacology
MH  - Glucagon-Like Peptide 1
MH  - Injections, Intraventricular
MH  - Male
MH  - Obesity/*genetics
MH  - Peptide Fragments/*pharmacology
MH  - Protein Precursors/*pharmacology
MH  - Rats
MH  - Rats, Zucker
EDAT- 1998/07/15 00:00
MHDA- 1998/07/15 00:01
CRDT- 1998/07/15 00:00
PHST- 1998/07/15 00:00 [pubmed]
PHST- 1998/07/15 00:01 [medline]
PHST- 1998/07/15 00:00 [entrez]
AID - S0196-9781(98)00033-3 [pii]
AID - 10.1016/s0196-9781(98)00033-3 [doi]
PST - ppublish
SO  - Peptides. 1998;19(5):869-75. doi: 10.1016/s0196-9781(98)00033-3.