PMID- 9665752
OWN - NLM
STAT- MEDLINE
DCOM- 19980805
LR  - 20120627
IS  - 0008-8749 (Print)
IS  - 0008-8749 (Linking)
VI  - 186
IP  - 2
DP  - 1998 Jun 15
TI  - Down-regulation of Fas-associated phosphatase-1 (FAP-1) in 
      interleukin-2-activated T cells.
PG  - 103-10
AB  - Peripheral T cells are resistant to Fas receptor (FasR/CD95)-mediated apoptosis. 
      After prolonged treatment with interleukin-2 (IL-2), these T cells develop a 
      Fas-sensitive phenotype. To clarify the molecular mechanism of apoptosis 
      susceptibility, mRNA expression of FasR-associated proteins [Fas-associating 
      protein with death domain (FADD), receptor-interacting protein (RIP), and 
      Fas-associated phosphatase-1 (FAP-1)] has been investigated in IL-2 activated T 
      cells. Competitive reverse transcriptase-polymerase chain reaction analysis 
      revealed that FADD and RIP mRNA were equally expressed in freshly isolated 
      resting T cells and IL-2-activated T cells. In contrast, FAP-1 mRNA was produced 
      more abundantly by Fas-resistant resting T cells than by Fas-sensitive activated 
      T cells. These findings suggested that sensitivity to FasR-mediated apoptosis in 
      T cells could be correlated with down-regulation of FAP-1 expression. 
      Additionally, CD45RO+ memory T cells expressed a larger amount of FAP-1 mRNA than 
      did CD45RA+ naive T cells.
FAU - Zhou, Y W
AU  - Zhou YW
AD  - Department of Pediatrics, Mie University School of Medicine, Japan.
FAU - Komada, Y
AU  - Komada Y
FAU - Inaba, H
AU  - Inaba H
FAU - Azuma, E
AU  - Azuma E
FAU - Sakurai, M
AU  - Sakurai M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (FADD protein, human)
RN  - 0 (FASLG protein, human)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (Fas-Associated Death Domain Protein)
RN  - 0 (Interleukin-2)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Mitogens)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.1 (RIPK1 protein, human)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
RN  - EC 3.1.3.16 (Protein Phosphatase 1)
RN  - EC 3.1.3.48 (PTPN13 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 13)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Apoptosis
MH  - Carrier Proteins/*biosynthesis/genetics
MH  - Cells, Cultured
MH  - *Down-Regulation
MH  - Fas Ligand Protein
MH  - Fas-Associated Death Domain Protein
MH  - Gene Expression
MH  - Humans
MH  - Interleukin-2/*pharmacology
MH  - Lymphocyte Activation/*physiology
MH  - Membrane Glycoproteins/metabolism
MH  - Mitogens/pharmacology
MH  - Protein Phosphatase 1
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 13
MH  - Protein Tyrosine Phosphatases/*biosynthesis/genetics
MH  - Proteins/genetics
MH  - RNA, Messenger
MH  - Receptor-Interacting Protein Serine-Threonine Kinases
MH  - T-Lymphocytes/drug effects/*metabolism
EDAT- 1998/07/17 00:00
MHDA- 1998/07/17 00:01
CRDT- 1998/07/17 00:00
PHST- 1998/07/17 00:00 [pubmed]
PHST- 1998/07/17 00:01 [medline]
PHST- 1998/07/17 00:00 [entrez]
AID - S0008-8749(98)91297-7 [pii]
AID - 10.1006/cimm.1998.1297 [doi]
PST - ppublish
SO  - Cell Immunol. 1998 Jun 15;186(2):103-10. doi: 10.1006/cimm.1998.1297.