PMID- 9666531
OWN - NLM
STAT- MEDLINE
DCOM- 19980917
LR  - 20170214
IS  - 1358-863X (Print)
IS  - 1358-863X (Linking)
VI  - 3
IP  - 1
DP  - 1998
TI  - Unfractionated versus low-molecular-weight heparin in the treatment of venous 
      thromboembolism.
PG  - 41-6
AB  - Low-molecular-weight heparin (LMWH) fractions are prepared from standard 
      unfractionated heparin (UFH) and are thus similar to UFH in many aspects. The 
      main advantages of this new class of antithrombotic agents as compared with UFH 
      are: (1) an improved bioavailability and a prolonged half-life, which alleviate 
      cumbersome laboratory monitoring and may permit one single daily subcutaneous 
      injection; and (2) an improved efficacy-to-safety ratio, with less bleeding 
      despite similar or improved efficacy. For these reasons, LMWH is progressively 
      replacing UFH for preventing postoperative thromboembolism and for treating 
      established deep vein thrombosis and pulmonary embolism. However, the effects of 
      the new compounds need to be evaluated carefully in some other indications 
      (arterial thrombosis, unstable angina, or myocardial infarction-the latter also 
      in conjunction with thrombolytic treatment) before they can generally replace UFH 
      in pharmacotherapy.
FAU - Bounameaux, H
AU  - Bounameaux H
AD  - Department of Internal Medicine, University of Geneva School of Medicine, 
      Switzerland.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
RN  - 0 (Anticoagulants)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Female
MH  - Heparin/therapeutic use
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Pregnancy
MH  - Pulmonary Embolism/prevention & control/*therapy
MH  - Thrombophlebitis/prevention & control/*therapy
RF  - 40
EDAT- 1998/07/17 00:00
MHDA- 1998/07/17 00:01
CRDT- 1998/07/17 00:00
PHST- 1998/07/17 00:00 [pubmed]
PHST- 1998/07/17 00:01 [medline]
PHST- 1998/07/17 00:00 [entrez]
AID - 10.1177/1358836X9800300109 [doi]
PST - ppublish
SO  - Vasc Med. 1998;3(1):41-6. doi: 10.1177/1358836X9800300109.