PMID- 9667665
OWN - NLM
STAT- MEDLINE
DCOM- 19980730
LR  - 20190515
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 77
IP  - 11
DP  - 1998 Jun
TI  - Cytogenetic and FISH analyses of pancreatic carcinoma reveal breaks in 18q11 with 
      consistent loss of 18q12-qter and frequent gain of 18p.
PG  - 1893-9
AB  - Chromosome 18 was analysed using a banding technique and fluorescence in situ 
      hybridization (FISH) in 13 pancreatic carcinoma samples. The cytogenetic analysis 
      revealed that chromosome 18 abnormalities were present in all cases and that 
      several different rearrangements, such as translocations, deletions, dicentrics 
      and ring chromosomes, were often found together. FISH mapping using 18q YAC 
      probes showed that all tumours had lost at least one copy of 18q and that 18p was 
      over-represented in 6 of the 13 cases. Furthermore, out of 13 identified deletion 
      breakpoints on 18q, 11 were mapped to 18q11. The clustering of breaks close to 
      the centromere indicates that loss of genes in bands 18q11 and 18q12, in addition 
      to those located in 18q21, e.g. DPC4 and DCC, are important in the development of 
      pancreatic tumours.
FAU - Hoglund, M
AU  - Hoglund M
AD  - Department of Clinical Genetics, University Hospital, Lund, Sweden.
FAU - Gorunova, L
AU  - Gorunova L
FAU - Jonson, T
AU  - Jonson T
FAU - Dawiskiba, S
AU  - Dawiskiba S
FAU - Andren-Sandberg, A
AU  - Andren-Sandberg A
FAU - Stenman, G
AU  - Stenman G
FAU - Johansson, B
AU  - Johansson B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
SB  - IM
MH  - Aged
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 18
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Pancreatic Neoplasms/*genetics
PMC - PMC2150326
EDAT- 1998/07/17 00:00
MHDA- 1998/07/17 00:01
CRDT- 1998/07/17 00:00
PHST- 1998/07/17 00:00 [pubmed]
PHST- 1998/07/17 00:01 [medline]
PHST- 1998/07/17 00:00 [entrez]
AID - 10.1038/bjc.1998.315 [doi]
PST - ppublish
SO  - Br J Cancer. 1998 Jun;77(11):1893-9. doi: 10.1038/bjc.1998.315.