PMID- 9668676
OWN - NLM
STAT- MEDLINE
DCOM- 19980813
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 844
DP  - 1998 May 30
TI  - Acute effects of dexfenfluramine (d-FEN) and methylenedioxymethamphetamine (MDMA) 
      before and after short-course, high-dose treatment.
PG  - 183-90
AB  - The acute behavioral effects of methylenedioxymethamphetamine (MDMA) and 
      dexfenfluramine (d-FEN) were assessed in six rhesus monkeys using performance in 
      the National Center for Toxicological Research (NCTR) Operant Test Battery (OTB); 
      three additional animals served as controls for neurochemical endpoints. The OTB 
      consists of five food-reinforced tasks designed to model aspects of learning, 
      short-term memory and attention, time estimation, motivation, and color and 
      position discrimination. Shortly after the acute effects of each drug were 
      determined, three of the monkeys received a short-course, high-dose exposure (2x 
      /day x 4 days, intramuscular (i.m.) injections) of MDMA (10 mg/kg), while three 
      monkeys were exposed to an identical regimen of d-FEN (5 mg/kg). Approximately 
      one month later, the acute effects of each drug were again determined. In monkeys 
      exposed to high-dose d-FEN, the sensitivities of the OTB tasks to acute 
      disruption by either MDMA or d-FEN were essentially unchanged. Conversely, 
      monkeys treated with high-dose MDMA were less sensitive to the acute behavioral 
      effects of both drugs, although such an effect was seen more frequently for d-FEN 
      and was OTB task specific. Thus a residual behavioral tolerance to the acute 
      behavioral effects of MDMA and d-FEN was noted after high-dose MDMA exposure, but 
      not after high-dose d-FEN exposure. These findings are surprising, as similar 
      neurochemical effects (i.e., significant decreases of ca. 50% in serotonin in 
      frontal cortex and hippocampus) were observed in all monkeys approximately six 
      months after short-course, high-dose MDMA or d-FEN treatment.
FAU - Frederick, D L
AU  - Frederick DL
AD  - Division of Neurotoxicology, National Center for Toxicological Research, 
      Jefferson Arkansas 72079, USA. df50029@GlaxoWellcome.com
FAU - Ali, S F
AU  - Ali SF
FAU - Gillam, M P
AU  - Gillam MP
FAU - Gossett, J
AU  - Gossett J
FAU - Slikker, W
AU  - Slikker W
FAU - Paule, M G
AU  - Paule MG
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 2DS058H2CF (Fenfluramine)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Drug Tolerance
MH  - Fenfluramine/*administration & dosage/pharmacology
MH  - Macaca mulatta
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/pharmacology
MH  - Neuropsychological Tests
MH  - Serotonin/metabolism
MH  - Time Factors
EDAT- 1998/07/21 00:00
MHDA- 1998/07/21 00:01
CRDT- 1998/07/21 00:00
PHST- 1998/07/21 00:00 [pubmed]
PHST- 1998/07/21 00:01 [medline]
PHST- 1998/07/21 00:00 [entrez]
PST - ppublish
SO  - Ann N Y Acad Sci. 1998 May 30;844:183-90.