PMID- 9669271
OWN - NLM
STAT- MEDLINE
DCOM- 19980722
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 32
IP  - 1
DP  - 1998 Jul
TI  - Resolution of cardiomyopathy after ablation of atrial flutter.
PG  - 205-10
AB  - OBJECTIVES: We sought to serially assess left ventricular (LV) function before 
      and after catheter ablation of atrial flutter (AFI). BACKGROUND: The relation of 
      tachycardia-induced cardiomyopathy to AFI and its response to direct catheter 
      ablation are unknown. METHODS: LV function was assessed in a series of 59 
      consecutive patients with successful radiofrequency ablation (RFA) of AFI before 
      and after the procedure. Eleven patients had dilated cardiomyopathy (LV ejection 
      fraction [LVEF] <50%) and congestive heart failure (CHF) symptoms and are the 
      subject of this report. LV function was assessed by LVEF on two-dimensional 
      echocardiography and functional status by New York Heart Association (NYHA) CHF 
      classification. RESULTS: Patients were 59 +/- 8 years old, and were all male. 
      Five patients had a preablation diagnosis of idiopathic cardiomyopathy. The 
      preablation LVEF was 30.9 +/- 11.0% and improved to 41.3 +/- 16% (p = 0.005) when 
      measured 7 months after successful ablation. NYHA CHF class improved from 2.6 +/- 
      0.5 to 1.6 +/- 0.9 (p = 0.002). Six (55%) of 11 patients had normalization of the 
      LVEF, with complete resolution of CHF symptoms. A lower preablation LVEF and 
      functional class predicted nonresolution of dilated cardiomyopathy (p = 0.002 and 
      0.001, respectively). CONCLUSIONS: Restoration of normal sinus rhythm by RFA in 
      patients with chronic AFI and cardiomyopathy substantially improved LV function. 
      Resolution of dilated cardiomyopathy occurred in the majority of patients. 
      Tachycardia-induced cardiomyopathy may be a more common mechanism of LV 
      dysfunction in patients with AFI than expected, and aggressive treatment of this 
      arrhythmia should be considered.
FAU - Luchsinger, J A
AU  - Luchsinger JA
AD  - Division of Cardiology, St. Luke's-Roosevelt Hospital Center, Columbia University 
      College of Physicians and Surgeons, New York, New York 10025, USA.
FAU - Steinberg, J S
AU  - Steinberg JS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atrial Flutter/diagnosis/physiopathology/*surgery
MH  - Cardiomyopathies/diagnosis/physiopathology/*surgery
MH  - Cardiomyopathy, Dilated/physiopathology/surgery
MH  - *Catheter Ablation
MH  - Electrocardiography, Ambulatory
MH  - Follow-Up Studies
MH  - Heart Atria/physiopathology/surgery
MH  - Heart Failure/physiopathology/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/physiology
MH  - Ventricular Function, Left/*physiology
EDAT- 1998/07/21 00:00
MHDA- 1998/07/21 00:01
CRDT- 1998/07/21 00:00
PHST- 1998/07/21 00:00 [pubmed]
PHST- 1998/07/21 00:01 [medline]
PHST- 1998/07/21 00:00 [entrez]
AID - S0735-1097(98)00183-1 [pii]
AID - 10.1016/s0735-1097(98)00183-1 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1998 Jul;32(1):205-10. doi: 10.1016/s0735-1097(98)00183-1.