PMID- 9669699
OWN - NLM
STAT- MEDLINE
DCOM- 19980909
LR  - 20210904
IS  - 1015-6305 (Print)
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Linking)
VI  - 8
IP  - 3
DP  - 1998 Jul
TI  - Microvascular and cellular responses in the retina of rats with acute 
      experimental allergic encephalomyelitis (EAE).
PG  - 487-98
AB  - The microvascular and cellular responses in the retina during acute EAE were 
      characterized using whole-mount preparations. The earliest detectable event was 
      the accumulation of monocytes and T cells within veins on day 7 postinduction 
      (pi). Mild breakdown of the blood-retinal barrier (BRB), activation of microglia 
      and infiltration of monocytes and T cells into the retinal parenchyma were first 
      evident on days 7 to 8 pi. Monocyte adhesion to the vessel wall and breakdown of 
      the BRB were colocalized in the same vessel segments and occurred predominantly 
      in veins. The marked difference in response observed in the retina versus the 
      myelinated region of the optic nerve suggests that two types of inflammatory 
      cascades are initiated. A mild response, characterised by very low numbers of T 
      cells and monocytes and an absence of expression of MHC class II by resident 
      microglia, is initiated when only small amounts of the encephalitogenic antigen 
      are present in the perivascular space or associated with perivascular 
      antigen-presenting cells. A full blown inflammatory reaction, as observed in the 
      optic nerve, is initiated in the presence of substantial amounts of 
      encephalitogenic antigen. This severe response is characterised by the 
      infiltration of large numbers of CD4+, CD8+ T cells and ED1+ monocytes, and by 
      abundant MHC class II expression by resident microglia as well as other cell 
      types. Thus, MHC class II expression by resident microglia may be a possible 
      effective amplifier mechanism if the encephalitogenic antigen is encountered in 
      the tissue parenchyma.
FAU - Hu, P
AU  - Hu P
AD  - Department of Anatomy and Histology, Institute of Biomedical Research, University 
      of Sydney, NSW, Australia.
FAU - Pollard, J
AU  - Pollard J
FAU - Hunt, N
AU  - Hunt N
FAU - Chan-Ling, T
AU  - Chan-Ling T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (Coloring Agents)
RN  - 0 (Indoles)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 3VEX9T7UT5 (copper phthalocyanine)
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/drug effects/*physiology
MH  - Coloring Agents
MH  - Encephalomyelitis, Autoimmune, Experimental/chemically 
      induced/immunology/*pathology
MH  - Horseradish Peroxidase
MH  - Indoles
MH  - Leukocytes/immunology
MH  - Male
MH  - Microcirculation/drug effects/pathology
MH  - Microglia/drug effects/pathology
MH  - Monocytes/immunology
MH  - Organometallic Compounds
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Receptors, Antigen, T-Cell, alpha-beta/immunology
MH  - Retina/immunology/metabolism/*pathology
MH  - Retinal Vessels/drug effects/immunology/metabolism/*pathology
MH  - Time Factors
PMC - PMC8098246
EDAT- 1998/07/21 00:00
MHDA- 1998/07/21 00:01
PMCR- 2006/04/05
CRDT- 1998/07/21 00:00
PHST- 1998/07/21 00:00 [pubmed]
PHST- 1998/07/21 00:01 [medline]
PHST- 1998/07/21 00:00 [entrez]
PHST- 2006/04/05 00:00 [pmc-release]
AID - BPA487 [pii]
AID - 10.1111/j.1750-3639.1998.tb00170.x [doi]
PST - ppublish
SO  - Brain Pathol. 1998 Jul;8(3):487-98. doi: 10.1111/j.1750-3639.1998.tb00170.x.