PMID- 9669836
OWN - NLM
STAT- MEDLINE
DCOM- 19980819
LR  - 20210823
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 22
IP  - 4
DP  - 1998 Apr
TI  - Trisomy 12 in chronic lymphocytic leukemia--geographical variation.
PG  - 313-7
AB  - Incidence of trisomy 12 was studied in 60 cases of chronic lymphocytic leukemia 
      (CLL) with chromosome 12 specific alpha-satellite DNA probe by fluorescence in 
      situ hybridization (FISH). Trisomy 12 was observed in 37 (61.8%) patients. Cells 
      with trisomy 12 were detected in a varying proportion, ranging from > 2% to 86%. 
      Patients with trisomy 12 were predominantly observed with total white blood cell 
      (WBC) count > 80 x 10(9) l(-1) (P < 0.001). In addition, the percentage of 
      trisomy 12 positive lymphocytes correlated with the high WBC counts. Trisomy 12 
      was observed equally in typical and atypical CLL. 90% of our patients were in the 
      intermediate and high risk groups. It was seen that there was significantly 
      higher percentage of trisomy 12 positive lymphocytes ( > 10%) in the high risk 
      groups (P < 0.05). A higher incidence of FMC7 positivity in atypical CLL was seen 
      in our study. However, there was no significant relationship found between 
      trisomy 12 positivity and expression of either FMC7 or CD23 in our cases. It 
      appears that the CLL that we see at our centre is at a different phase of 
      evolution and perhaps biologically different compared to the CLL seen in the 
      West.
FAU - Nair, C N
AU  - Nair CN
AD  - Tata Memorial Hospital, Parel Mumbai, India. drnair@poboxes.com
FAU - Chougule, A
AU  - Chougule A
FAU - Dhond, S
AU  - Dhond S
FAU - Goyal, R
AU  - Goyal R
FAU - Parikh, P M
AU  - Parikh PM
FAU - Pai, S
AU  - Pai S
FAU - Telang, D
AU  - Telang D
FAU - Advani, S H
AU  - Advani SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (CD5 Antigens)
RN  - 0 (Glycoproteins)
RN  - 0 (MS4A1 protein, human)
RN  - 0 (Receptors, IgE)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - CD5 Antigens/analysis
MH  - Chromosomes, Human, Pair 12/*genetics
MH  - Female
MH  - Glycoproteins/analysis
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Incidence
MH  - India/epidemiology
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/classification/epidemiology/*genetics
MH  - Leukocyte Count
MH  - Lymphocytes/immunology
MH  - Male
MH  - Middle Aged
MH  - Receptors, IgE/analysis
MH  - *Trisomy
EDAT- 1998/07/21 00:00
MHDA- 1998/07/21 00:01
CRDT- 1998/07/21 00:00
PHST- 1998/07/21 00:00 [pubmed]
PHST- 1998/07/21 00:01 [medline]
PHST- 1998/07/21 00:00 [entrez]
AID - S0145212697001690 [pii]
AID - 10.1016/s0145-2126(97)00169-0 [doi]
PST - ppublish
SO  - Leuk Res. 1998 Apr;22(4):313-7. doi: 10.1016/s0145-2126(97)00169-0.