PMID- 9669995
OWN - NLM
STAT- MEDLINE
DCOM- 20040921
LR  - 20190831
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 3
DP  - 1998 Jul 23
TI  - Integrin-mediated platelet adhesion.
PG  - d719-28
AB  - Adhesion of platelets to the damaged subendothelium is a prerequisite reaction 
      for the initiation of hemostasis in vivo. Platelet membranes contain high 
      concentrations of integrins and other glycoproteins (GPs) that are involved in 
      the platelet adhesion to the extracellular matrix. In the present review, we 
      focus on two platelet integrins, integrin alphaIIb beta3 (GPIIb/IIIa) and 
      integrin alpha2 beta1 (GPIa/IIa) because these integrins are major components of 
      the platelet membrane proteins and are known to contribute to platelet adhesion 
      to fibrin(ogen) and collagen surfaces, respectively. These integrins bind soluble 
      ligands (fibrinogen or collagen) after platelets are activated but only have low 
      affinity towards these ligands when platelets are in the resting state. We 
      describe the binding properties of these integrins and discuss the mechanism for 
      the activation of these integrins. Platelets can adhere to fibrin(ogen) or 
      collagen immobilized on a surface. When platelets adhere to a collagen- or 
      fibrin-coated surface, they become activated and form aggregates; this is 
      especially prominent under flow conditions. We discuss the contribution of these 
      integrins and non-integrin proteins, GPIb and GPVI, to the platelet adhesion on 
      to the collagen surface, especially under flow conditions, a system that most 
      closely approximates platelet adhesion in vivo.
FAU - Moroi, M
AU  - Moroi M
AD  - Department of Protein Biochemistry, Institute of Life Science, Kurume University, 
      Kurume-shi, Fukuoka-ken Japan. moroi@lsi.kurume-u.ac.jp
FAU - Jung, S M
AU  - Jung SM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 19980723
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
RN  - 0 (Integrins)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Integrins/*physiology
MH  - Platelet Adhesiveness/*physiology
RF  - 92
EDAT- 1998/07/22 00:00
MHDA- 2004/09/24 05:00
CRDT- 1998/07/22 00:00
PHST- 1998/07/22 00:00 [pubmed]
PHST- 2004/09/24 05:00 [medline]
PHST- 1998/07/22 00:00 [entrez]
AID - 10.2741/a315 [doi]
PST - epublish
SO  - Front Biosci. 1998 Jul 23;3:d719-28. doi: 10.2741/a315.