PMID- 9677201
OWN - NLM
STAT- MEDLINE
DCOM- 19980813
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 281
IP  - 5376
DP  - 1998 Jul 24
TI  - An unusual mechanism for ligand antagonism.
PG  - 568-72
AB  - The ratio of late to early events stimulated by the mast cell receptor for 
      immunoglobulin E (IgE) correlated with the affinity of a ligand for the 
      receptor-bound IgE. Because excess receptors clustered by a weakly binding ligand 
      could hoard a critical initiating kinase, they prevented the outnumbered clusters 
      engendered by the high-affinity ligands from launching the more complete cascade. 
      A similar mechanism could explain the antagonistic action of some peptides on the 
      activation of T cells.
FAU - Torigoe, C
AU  - Torigoe C
AD  - Arthritis and Rheumatism Branch, National Institute of Arthritis and 
      Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 
      20892-1820, USA.
FAU - Inman, J K
AU  - Inman JK
FAU - Metzger, H
AU  - Metzger H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Dansyl Compounds)
RN  - 0 (Enzyme Precursors)
RN  - 0 (Haptens)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Ligands)
RN  - 0 (Nck protein)
RN  - 0 (Oncogene Proteins)
RN  - 0 (Receptors, IgE)
RN  - 21820-51-9 (Phosphotyrosine)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.2 (Focal Adhesion Kinase 2)
RN  - EC 2.7.10.2 (Ptk2b protein, rat)
RN  - EC 2.7.10.2 (Syk Kinase)
RN  - EC 2.7.10.2 (Syk protein, rat)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - Q13SKS21MN (2,4-Dinitrophenol)
SB  - IM
CIN - Science. 1998 Jul 24;281(5376):528-9. PMID: 9705722
MH  - 2,4-Dinitrophenol/immunology
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Antibody Affinity
MH  - Antigen-Antibody Reactions
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Dansyl Compounds
MH  - Enzyme Precursors/metabolism
MH  - Focal Adhesion Kinase 2
MH  - Haptens/*immunology/metabolism
MH  - Immunoglobulin E/immunology/*metabolism
MH  - Intracellular Signaling Peptides and Proteins
MH  - Ligands
MH  - Mast Cells/*immunology
MH  - Mitogen-Activated Protein Kinase 1
MH  - Oncogene Proteins/metabolism
MH  - Phosphorylation
MH  - Phosphotyrosine/metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Rats
MH  - Receptor Aggregation
MH  - Receptors, IgE/immunology/*metabolism
MH  - Signal Transduction
MH  - Syk Kinase
MH  - T-Lymphocytes/immunology
MH  - Tumor Cells, Cultured
EDAT- 1998/07/24 00:00
MHDA- 1998/07/24 00:01
CRDT- 1998/07/24 00:00
PHST- 1998/07/24 00:00 [pubmed]
PHST- 1998/07/24 00:01 [medline]
PHST- 1998/07/24 00:00 [entrez]
AID - 10.1126/science.281.5376.568 [doi]
PST - ppublish
SO  - Science. 1998 Jul 24;281(5376):568-72. doi: 10.1126/science.281.5376.568.