PMID- 9678803
OWN - NLM
STAT- MEDLINE
DCOM- 19980915
LR  - 20071115
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 22
IP  - 1
DP  - 1998 Jul
TI  - Isolated extramedullary relapse after allogeneic bone marrow transplantation for 
      chronic myeloid leukemia.
PG  - 99-102
AB  - Relapse of chronic myeloid leukemia (CML) as extramedullary granulocytic sarcoma 
      (GS) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. We 
      report two patients who developed spinal GS as the first indication of relapse 
      after allogeneic BMT for CML. In both cases, the marrow was in morphologic and 
      karyotypic remission. However, fluorescence in situ hybridization (FISH) 
      successfully demonstrated the presence of a minor Ph-positive clone in the 
      marrow, as well as an occult clone with an additional Ph chromosome detected in 
      one case. The results indicated a stronger graft-versus-leukemia effect in the 
      marrow than in the peripheral tissues.
FAU - Au, W Y
AU  - Au WY
AD  - University Department of Medicine, Queen Mary Hospital, Hong Kong.
FAU - Chan, A C
AU  - Chan AC
FAU - Lie, A K
AU  - Lie AK
FAU - So, J C
AU  - So JC
FAU - Liang, R
AU  - Liang R
FAU - Kwong, Y L
AU  - Kwong YL
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Fatal Outcome
MH  - Graft vs Host Disease/drug therapy/*prevention & control
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*diagnosis/*therapy
MH  - Male
MH  - Recurrence
MH  - Spinal Neoplasms/*diagnosis
MH  - Transplantation Conditioning
EDAT- 1998/07/25 00:00
MHDA- 1998/07/25 00:01
CRDT- 1998/07/25 00:00
PHST- 1998/07/25 00:00 [pubmed]
PHST- 1998/07/25 00:01 [medline]
PHST- 1998/07/25 00:00 [entrez]
AID - 10.1038/sj.bmt.1701294 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 1998 Jul;22(1):99-102. doi: 10.1038/sj.bmt.1701294.