PMID- 9679956
OWN - NLM
STAT- MEDLINE
DCOM- 19980807
LR  - 20220129
IS  - 0008-5472 (Print)
IS  - 0008-5472 (Linking)
VI  - 58
IP  - 14
DP  - 1998 Jul 15
TI  - The DAM gene family encodes a new group of tumor-specific antigens recognized by 
      human leukocyte antigen A2-restricted cytotoxic T lymphocytes.
PG  - 2969-72
AB  - The DAM family of genes has a high degree of homology with MAGE, both in 
      nucleotide sequence and in neoplastic tissue-specific expression. This study 
      describes, for the first time, the identification of CTLs specific for a peptide 
      epitope encoded by DAM genes. A human leukocyte antigen (HLA)-A2-restricted CTL 
      clone was raised against a peptide, D10/6-271, encoded by codons 271-279 in the 
      DAM cDNA. The corresponding peptide in the MAGE-3 sequence, M3-271, has been 
      shown previously to be a natural T-cell epitope for HLA-A2-restricted CTLs 
      recognizing the MAGE-3 protein. The D10/6-271-specific CTL clone required 
      approximately 3 nM exogenous peptide for half-maximal lysis of target cells and 
      was able to specifically recognize endogenous DAM antigen on HLA-A2+ melanoma 
      cells infected with a vaccinia vector recombinant for gene DAM-6. These data 
      suggest that DAM genes might encode a new group of tumor-specific antigens useful 
      for the design of specific antitumor vaccines.
FAU - Fleischhauer, K
AU  - Fleischhauer K
AD  - Telethon Institute of Gene Therapy, Istituto Scientifico H. S. Raffaele, Milan, 
      Italy. fleisck@tigem.it
FAU - Gattinoni, L
AU  - Gattinoni L
FAU - Dalerba, P
AU  - Dalerba P
FAU - Lauvau, G
AU  - Lauvau G
FAU - Zanaria, E
AU  - Zanaria E
FAU - Dabovic, B
AU  - Dabovic B
FAU - van Endert, P M
AU  - van Endert PM
FAU - Bordignon, C
AU  - Bordignon C
FAU - Traversari, C
AU  - Traversari C
LA  - eng
GR  - 51/BS/TI_/Telethon/Italy
GR  - TGT06S01/TI_/Telethon/Italy
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Res
JT  - Cancer research
JID - 2984705R
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (MAGEB2 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Peptides)
SB  - IM
MH  - Antigens, Neoplasm/genetics/*immunology
MH  - HLA Antigens/*immunology
MH  - HLA-A2 Antigen/immunology
MH  - Humans
MH  - Immunotherapy
MH  - Neoplasm Proteins/*genetics/immunology
MH  - Neoplasms/therapy
MH  - Peptides/immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Tumor Cells, Cultured
EDAT- 1998/07/29 00:00
MHDA- 1998/07/29 00:01
CRDT- 1998/07/29 00:00
PHST- 1998/07/29 00:00 [pubmed]
PHST- 1998/07/29 00:01 [medline]
PHST- 1998/07/29 00:00 [entrez]
PST - ppublish
SO  - Cancer Res. 1998 Jul 15;58(14):2969-72.