PMID- 9681849
OWN - NLM
STAT- MEDLINE
DCOM- 19980813
LR  - 20190905
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 243
IP  - 6
DP  - 1998 Jun
TI  - Thymic carcinoids in multiple endocrine neoplasia type 1.
PG  - 501-4
AB  - Thymic carcinoid is a rare malignancy with about 150 cases reported to date. It 
      is associated with multiple endocrine neoplasia type 1 (MEN-1), but compared with 
      other MEN-1-related neoplasia little is known about it. We have recently 
      described and studied 20 MEN-1-related cases and found that up to 25% of all 
      reported thymic carcinoids are MEN-1 related. It is an insidious tumour not 
      associated with Cushing's syndrome or carcinoid syndrome. Local invasion, 
      recurrence and distant metastasis are common with no known effective treatment. 
      Its male predominance, the absence of loss of heterozygosity (LOH) in the MEN1 
      region, clustering in some MEN-1 families and the findings of different MEN1 
      mutations in these clustered families suggest the involvement of additional 
      aetiological factors. We propose that computed tomography (CT) or magnetic 
      resonance imaging (MRI) of the chest should be included as part of the clinical 
      workup for all MEN-1 patients. Prophylactic thymectomy should be considered 
      during subtotal or total parathyroidectomy on MEN-1 patients to reduce the risk 
      of this malignancy.
FAU - Teh, B T
AU  - Teh BT
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden. 
      bin.teh@cmm.ki.se
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Carcinoid Tumor/diagnosis/*genetics/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Thymus Neoplasms/diagnosis/*genetics/therapy
RF  - 14
EDAT- 1998/07/29 00:00
MHDA- 1998/07/29 00:01
CRDT- 1998/07/29 00:00
PHST- 1998/07/29 00:00 [pubmed]
PHST- 1998/07/29 00:01 [medline]
PHST- 1998/07/29 00:00 [entrez]
AID - 10.1046/j.1365-2796.1998.00329.x [doi]
PST - ppublish
SO  - J Intern Med. 1998 Jun;243(6):501-4. doi: 10.1046/j.1365-2796.1998.00329.x.