PMID- 9682928
OWN - NLM
STAT- MEDLINE
DCOM- 19981022
LR  - 20071115
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 52
IP  - 1
DP  - 1998 Feb
TI  - Pharmacotherapy for personality disorders.
PG  - 13-9
AB  - Double-blind, placebo-controlled trials of pharmacotherapy for personality 
      disorders (PD) were reviewed, and the indications concluded were as follows: (1) 
      Severe cases of both Borderline Personality Disorder (BDP) and Schizotypal 
      Personality Disorder (SPD) respond to low dose antipsychotic drugs resulting in 
      improvement of a broad spectrum of symptoms. They also respond to monoamine 
      oxidase inhibitor (MAOI). Amitriptyline causes a paradoxical effect. (2) 
      Borderline personality disorder with behavioral dyscontrol responds to 
      carbamazepine which reduces actual episodes of dyscontrol, to an antipsychotic 
      drug and to MAOI. Alprazolam is associated with an increase in suicidality and 
      dyscontrol. Borderline personal disorder or Histrionic Personality Disorder with 
      a tendency to suicide, responds to a depot antipsychotic drug. Personality 
      disorders with aggressive behavior respond to lithium. Moderately severe PD with 
      explosive behavior respond to oxazepam, but at a dose where the side effect is 
      sedation. (3) Borderline personality disorder and SPD with psychotic symptoms 
      respond to an antipsychotic drug which improves psychotic symptoms as well as 
      neurotic symptoms. Emotionally Unstable Character Disorder with a disturbance of 
      mood swings, responds to lithium. Adolescent PD respond to an antipsychotic drug. 
      (4) Comorbid atypical depression of histrionic personality and BPD respond to 
      MAOI or imipramine. Comorbid neurotic disorder of PD responds to dothiepin. 
      Comorbid social phobia of avoidant and dependent PD responds to MAOI.
FAU - Hori, A
AU  - Hori A
AD  - Department of Psychiatry, National Center Hospital for Mental, Nervous and 
      Muscular Disorders, Kodaira, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Antipsychotic Agents/adverse effects/therapeutic use
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Humans
MH  - Personality Disorders/diagnosis/*drug therapy/psychology
MH  - Psychotropic Drugs/adverse effects/*therapeutic use
RF  - 27
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
AID - 10.1111/j.1440-1819.1998.tb00967.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 1998 Feb;52(1):13-9. doi: 
      10.1111/j.1440-1819.1998.tb00967.x.