PMID- 9682978
OWN - NLM
STAT- MEDLINE
DCOM- 19981001
LR  - 20190905
IS  - 0340-2061 (Print)
IS  - 0340-2061 (Linking)
VI  - 197
IP  - 6
DP  - 1998 Jun
TI  - Retinoid X receptor-gamma gene expression is developmentally regulated in the 
      embryonic rodent peripheral nervous system.
PG  - 477-84
AB  - The retinoid X receptor-gamma (RXRgamma) is a transcription factor that belongs 
      to the thyroid hormone/retinoid family of nuclear receptors. Previous studies 
      have shown that RXRgamma is expressed in the developing peripheral nervous system 
      (PNS) of chick embryos, but such expression has not been reported previously in 
      rodent embryos. Indeed, the pattern of RXRgamma expression appears to be 
      different between avian and rodent species. Using in situ hybridisation and 
      northern blot experiments we show that RXRgamma is expressed in elements of the 
      PNS in rat and mouse embryos and in postnatal rats. However, unlike the chick, 
      where RXRgamma is expressed from the onset of neural crest migration, rat 
      RXRgamma expression in the dorsal root ganglia and trigeminal ganglia was 
      detectable at 14.5 days post coitum (dpc), but not at 13, 12, or 11 dpc. These 
      data suggest that RXRgamma may have a role in the dorsal root ganglia and 
      trigeminal ganglia of late embryos, and that this could be evolutionarily 
      conserved between chick and rodent. On the other hand, rat RXRgamma transcripts 
      in the facio-acoustic (VII-VIII) ganglion were detectable at 11 dpc in neural 
      crest cells condensing to form this ganglion. We discuss the possible 
      significance of the timing of RXRgamma expression in the developing PNS and 
      suggest that closer examination of the structure and function of the PNS of 
      RXRgamma null mutant mice would be of interest.
FAU - Georgiades, P
AU  - Georgiades P
AD  - Department of Molecular Pathology, University College London Medical School, UK. 
      pg3@mole.bio.cam.ac.uk
FAU - Wood, J
AU  - Wood J
FAU - Brickell, P M
AU  - Brickell PM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Anat Embryol (Berl)
JT  - Anatomy and embryology
JID - 7505194
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Mice
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Peripheral Nervous System/*embryology/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Receptors, Retinoic Acid/genetics/*metabolism
MH  - Retinoid X Receptors
MH  - Transcription Factors/genetics/*metabolism
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
AID - 10.1007/s004290050158 [doi]
PST - ppublish
SO  - Anat Embryol (Berl). 1998 Jun;197(6):477-84. doi: 10.1007/s004290050158.