PMID- 9683045
OWN - NLM
STAT- MEDLINE
DCOM- 19981106
LR  - 20190512
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 11
IP  - 7
DP  - 1998 Jul
TI  - Urinary calcium/creatinine ratio as a predictor of preeclampsia.
PG  - 839-43
AB  - Hypocalciuria has been associated with preeclampsia (gestational hypertension 
      with proteinuria or other maternal organ dysfunction) but not usually with pure 
      gestational hypertension or normal pregnancy. We hypothesized that hypocalciuria 
      would be a marker of emerging preeclampsia in women presenting with gestational 
      hypertension who later developed preeclampsia. Eighty-one women with de novo 
      hypertension in the second half of pregnancy (n = 81) were enrolled 
      prospectively. At first assessment, calcium/creatinine ratio was determined in a 
      spot urine. Patients were followed until delivery and were classified 
      subsequently according to the occurrence of preeclampsia. Gestational 
      hypertensive patients who became preeclamptic (n = 31) had lower urinary 
      calcium/creatinine ratios at presentation (ratio = 0.07, interquartile range 
      [IQR] = 0.04-0.11) than women who remained as gestational hypertensives (n = 50; 
      ratio = 0.17, IQR = 0.08-0.21; P = .002). Intact plasma parathyroid hormone (PTH) 
      concentrations were similar between groups. Using a receiver operator curve, the 
      best threshold value for the development of preeclampsia was a calcium/creatinine 
      ratio of 0.10, which yielded a sensitivity of only 68% and a specificity of 70%. 
      A low calcium/creatinine ratio preceded the emergence of preeclampsia by 12 
      (7-24) (median [IQR]) days among a group of women with gestational hypertension. 
      Though this implies primary or secondary disturbances of renal calcium handling 
      even before preeclampsia is clinically apparent, this measurement does not have 
      sufficient sensitivity to recommend its use as a screening test for the emergence 
      of preeclampsia.
FAU - Saudan, P J
AU  - Saudan PJ
AD  - Department of Renal Medicine, St. George Hospital, University of New South Wales, 
      Kogarah, Australia.
FAU - Shaw, L
AU  - Shaw L
FAU - Brown, M A
AU  - Brown MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Biomarkers)
RN  - 0 (Parathyroid Hormone)
RN  - AYI8EX34EU (Creatinine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood/urine
MH  - Calcium/*urine
MH  - Creatinine/*urine
MH  - Female
MH  - Humans
MH  - Parathyroid Hormone/blood
MH  - Pre-Eclampsia/*urine
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Trimesters/blood/urine
MH  - Sensitivity and Specificity
MH  - Time Factors
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
AID - S0895-7061(98)00054-5 [pii]
AID - 10.1016/s0895-7061(98)00054-5 [doi]
PST - ppublish
SO  - Am J Hypertens. 1998 Jul;11(7):839-43. doi: 10.1016/s0895-7061(98)00054-5.