PMID- 9683070
OWN - NLM
STAT- MEDLINE
DCOM- 19980925
LR  - 20190522
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 10
IP  - 3
DP  - 1998 Jul
TI  - Prior infection of nursery-age pigs with porcine reproductive and respiratory 
      syndrome virus does not affect the outcome of transmissible gastroenteritis virus 
      challenge.
PG  - 221-8
AB  - Thirty-six specific-pathogen-free pigs were weaned at 2 weeks of age and 
      separated into 4 treatment groups (A-D, 9 pigs/group). Treatment groups B and D 
      were infected with porcine reproductive and respiratory syndrome virus (PRRSV), 
      whereas groups A and C remained uninfected. Two weeks later, 1 pig from each 
      group was necropsied to assess gross lung involvement, and then the remaining 
      group D PRRSV-infected pigs and the group C uninfected pigs were challenged at 4 
      weeks of age with transmissible gastroenteritis virus (TGEV) to determine if 
      prior infection with PRRSV increased the severity of TGEV disease after 
      challenge. One hundred percent morbidity but no mortality occurred in pigs 
      following challenge. Clinically, pigs of both groups C and D were similar in 
      terms of onset and severity of diarrhea. The serum antibody response to TGEV and 
      the amount and duration of TGEV shedding after challenge was similar for both 
      groups. Only a few pigs in each group had a transient fever postchallenge, and 
      both group C and group D pigs began to recover and to gain weight at or near the 
      end of the first week postchallenge. It was concluded that the clinical course of 
      TGEV disease was not markedly affected by infection of pigs with TGEV 2 weeks 
      after they had been infected with PRRSV.
FAU - Wesley, R D
AU  - Wesley RD
AD  - Virology Swine Research Unit, National Animal Disease Center, Agricultural 
      Research Service, USDA, Ames, IA 50010, USA.
FAU - Mengeling, W L
AU  - Mengeling WL
FAU - Lager, K M
AU  - Lager KM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Gastroenteritis, Transmissible, of 
      Swine/complications/epidemiology/*physiopathology
MH  - Lung/pathology
MH  - Morbidity
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/growth & development
MH  - Swine
MH  - Time Factors
MH  - Weight Gain
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
AID - 10.1177/104063879801000301 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 1998 Jul;10(3):221-8. doi: 10.1177/104063879801000301.