PMID- 9683343
OWN - NLM
STAT- MEDLINE
DCOM- 19981022
LR  - 20190831
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 61
IP  - 2
DP  - 1998 Jun
TI  - Suppression of immunoglobulin E-mediated anaphylactic reaction by 
      Hwanglyun-Haedok-Tang water extract.
PG  - 127-34
AB  - According to traditional Oriental philosophy, Hwanglyun-Haedok-Tang (HH-Tang) is 
      a prescription for heat clearing of the organism. This prescription has been used 
      against allergic diseases for generations, and still occupies an important place 
      in traditional medicine in Korea. In this study, we investigated the effect of 
      HH-Tang water extract on immunoglobulin E (IgE)-mediated anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE antibody. HH-Tang water extract potently suppressed 
      passive cutaneous anaphylaxis (PCA) when intradermally, intraperitoneally, or 
      orally administered. On the other hand, it showed weak suppressive activity when 
      administered intravenously. HH-Tang water extract, dose-dependently suppressed 
      anaphylactic histamine release from rat peritoneal mast cells (RPMC) activated by 
      anti-DNP IgE antibody. Moreover, HH-Tang water extract had a significant 
      suppressive effect on anti-DNP IgE antibody-induced tumor necrosis factor-alpha 
      secretion from RPMC. The level of cAMP in RPMC, when HH-Tang water extract was 
      added, significantly increased compared with that of normal control. These 
      results indicate that HH-Tang water extract may possess strong antianaphylactic 
      action and also suggest that differential activity following administration 
      routes may be caused by difference of bioavailability.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 
      Iksan-city, Chonbuk, South Korea.
FAU - Park, Y
AU  - Park Y
FAU - Lee, E H
AU  - Lee EH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - E0399OZS9N (Cyclic AMP)
RN  - Q13SKS21MN (2,4-Dinitrophenol)
SB  - IM
MH  - 2,4-Dinitrophenol/antagonists & inhibitors/toxicity
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Histamine Release/drug effects
MH  - Immunoglobulin E/*immunology
MH  - Mast Cells/metabolism
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - Peritoneal Cavity/cytology
MH  - Plant Extracts/pharmacology
MH  - Plants, Medicinal/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
AID - S0378-8741(98)00024-5 [pii]
AID - 10.1016/s0378-8741(98)00024-5 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 1998 Jun;61(2):127-34. doi: 10.1016/s0378-8741(98)00024-5.