PMID- 9684522
OWN - NLM
STAT- MEDLINE
DCOM- 19980819
LR  - 20150901
IS  - 0001-6578 (Print)
IS  - 0001-6578 (Linking)
VI  - 39
IP  - 3
DP  - 1998 May-Jun
TI  - In vitro production of cytokines and allergen-specific IgE in bronchial asthmatic 
      children with different disease activity.
PG  - 173-9
AB  - The aim of this study was to further investigate the cytokine profile and the 
      level of allergen-specific immunoglobulin E (IgE) and IgG4 in asthmatic children 
      of different disease activity. Peripheral blood mononuclear cells were isolated 
      from seventy asthmatic children who had been newly diagnosed (N = 21), had good 
      (N = 20) or poor response (N = 12) to immunotherapy or during acute attack (N = 
      17) and from twenty normal children. Cytokines produced by both PHA and mite 
      allergen stimulated peripheral blood mononuclear cells (PBMCs) were assayed. 
      Resulting data suggested: 1) the level of IgE anti-house dust mite (HDM) antibody 
      was higher in asthmatic children with poor response to immunotherapy; in 
      contrast, among the five groups the level of IgG4 anti-HDM antibody was the 
      highest in asthmatic children with good response to immunotherapy among the five 
      groups; 2) the level of interferon-gamma (IFN-gamma) produced by mite-stimulated 
      PBMCs was the highest in asthmatic children with good response to immunotherapy 
      among the five groups; in contrast, the level of interleukin-4 (IL-4) was the 
      highest in the group of newly diagnosed asthmatic children; 3) the level of IL-13 
      was higher in asthmatic children with poor response to immunotherapy compared to 
      those of the other groups; 4) a higher level of IL-10 and lower level of IL-12 
      were noted in groups of both good and poor response to immunotherapy compared to 
      those of other groups. Although more studies are needed, the change of cytokines 
      in asthmatic children with different disease activity or response to 
      immunotherapy might shed light on further understanding of the regulatory 
      mechanisms of atopic diseases.
FAU - Chiang, B L
AU  - Chiang BL
AD  - Department of Pediatrics, College of Medicine, National Taiwan University, 
      Taipei, Taiwan, R.O.C. gicmbor@ha.mc.ntu.edu.tw
FAU - Tsai, M J
AU  - Tsai MJ
FAU - Chou, C C
AU  - Chou CC
FAU - Hsieh, K H
AU  - Hsieh KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China (Republic : 1949- )
TA  - Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi
JT  - Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er 
      ke yi xue hui
JID - 16210470R
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Dust)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/*immunology
MH  - Child
MH  - Cytokines/*biosynthesis
MH  - Dust
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Immunoglobulin G/biosynthesis/classification
MH  - Male
MH  - Mites/*immunology
EDAT- 1998/07/31 00:00
MHDA- 1998/07/31 00:01
CRDT- 1998/07/31 00:00
PHST- 1998/07/31 00:00 [pubmed]
PHST- 1998/07/31 00:01 [medline]
PHST- 1998/07/31 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1998 May-Jun;39(3):173-9.