PMID- 9685048
OWN - NLM
STAT- MEDLINE
DCOM- 19980929
LR  - 20190921
IS  - 0260-437X (Print)
IS  - 0260-437X (Linking)
VI  - 18
IP  - 3
DP  - 1998 May-Jun
TI  - Developmental toxicity study in Sprague-Dawley rats by whole-body exposure to 
      N,N-diethylethanolamine vapor.
PG  - 191-6
AB  - Timed-pregnant Sprague-Dawley rats were exposed whole body to 
      N,N-diethylethanolamine vapor for 6 h per day on gestational days (GD) 6-15 at 
      targeted concentrations of 33, 66 or 100 ppm. Dams were sacrificed on GD 21. 
      There was no maternal mortality in any exposed groups. Maternal toxicity observed 
      in the 100 ppm group included dry rales, reduced body weight (9.5%) on GD 15 and 
      reduced weight gain (48%) during exposure. Suppression of body weight gain was 
      also noted in the 66 ppm group during GD 12-15. There were no effects of 
      treatment on gestational parameters, including pre- and post-implantation loss or 
      sex ratio. Mean fetal body weights in treated groups were comparable to controls. 
      There was no increase in the incidence of total malformations (external, visceral 
      or skeletal) or individually by category. The incidence of a single developmental 
      variation (hypoplastic bones of the forepaw) in the 100 ppm groups was 
      statistically significantly decreased relative to that of controls. The 
      no-observed-adverse-effect level was 33 ppm for maternal toxicity but greater 
      than 100 ppm for embryofetal toxicity and teratogenicity.
FAU - Leung, H W
AU  - Leung HW
AD  - Union Carbide Corporation, Danbury, CT 06817, USA. leunghw@ucarb.com
FAU - Murphy, S R
AU  - Murphy SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Ethanolamines)
RN  - S6DL4M053U (2-diethylaminoethanol)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Embryonic and Fetal Development/*drug effects
MH  - Ethanolamines/administration & dosage/pharmacology/*toxicity
MH  - Female
MH  - Inhalation Exposure
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Weight Gain/drug effects
EDAT- 1998/07/31 02:06
MHDA- 2000/06/20 09:00
CRDT- 1998/07/31 02:06
PHST- 1998/07/31 02:06 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1998/07/31 02:06 [entrez]
AID - 10.1002/(SICI)1099-1263(199805/06)18:3<191::AID-JAT498>3.0.CO;2-5 [pii]
AID - 10.1002/(sici)1099-1263(199805/06)18:3<191::aid-jat498>3.0.co;2-5 [doi]
PST - ppublish
SO  - J Appl Toxicol. 1998 May-Jun;18(3):191-6. doi: 
      10.1002/(sici)1099-1263(199805/06)18:3<191::aid-jat498>3.0.co;2-5.