PMID- 9685685
OWN - NLM
STAT- MEDLINE
DCOM- 19980923
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 400
IP  - 1-2
DP  - 1998 May 25
TI  - 137Cesium-induced chromosome aberrations analyzed by fluorescence in situ 
      hybridization: eight years follow up of the Goiania radiation accident victims.
PG  - 299-312
AB  - The radiation accident in focus here occurred in a section of Goiania (Brazil) 
      where more than a hundred individuals were contaminated with 137Cesium on 
      September 1987. In order to estimate the absorbed radiation doses, initial 
      frequencies of dicentrics and rings were determined in 129 victims [A.T. Ramalho, 
      PhD Thesis, Subsidios a tecnica de dosimetria citogenetica gerados a partir da 
      analise de resultados obtidos com o acidente radiologico de Goiania, Universidade 
      Federal do Rio de Janeiro, Rio de Janeiro, Brazil, 1992]. We have followed some 
      of these victims cytogenetically over the years seeking for parameters that could 
      be used as basis for retrospective radiation dosimetry. Our data on translocation 
      frequencies obtained by fluorescence in situ hybridization (FISH) could be 
      directly compared to the baseline frequencies of dicentrics available for those 
      same victims. Our results provided valuable information on how precise these 
      estimates are. The frequencies of translocations observed years after the 
      radiation exposure were two to three times lower than the initial dicentrics 
      frequencies, the differences being larger at higher doses (>1 Gy). The accuracy 
      of such dose estimates might be increased by scoring sufficient amount of cells. 
      However, factors such as the persistence of translocation carrying lymphocytes, 
      translocation levels not proportional to chromosome size, and inter-individual 
      variation reduce the precision of these estimates.
CI  - Copyright 1998 Elsevier Science B.V. All rights reserved.
FAU - Natarajan, A T
AU  - Natarajan AT
AD  - LUMC, Leiden University Medical Centrum, Department of Radiation Genetics and 
      Chemical Mutagenesis, Wassenaarseweg 72, 2333 AL Leiden, Netherlands. 
      natarajan@rullf2medfac.leidenuniv.nl
FAU - Santos, S J
AU  - Santos SJ
FAU - Darroudi, F
AU  - Darroudi F
FAU - Hadjidikova, V
AU  - Hadjidikova V
FAU - Vermeulen, S
AU  - Vermeulen S
FAU - Chatterjee, S
AU  - Chatterjee S
FAU - Berg, M
AU  - Berg M
FAU - Grigorova, M
AU  - Grigorova M
FAU - Sakamoto-Hojo, E T
AU  - Sakamoto-Hojo ET
FAU - Granath, F
AU  - Granath F
FAU - Ramalho, A T
AU  - Ramalho AT
FAU - Curado, M P
AU  - Curado MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Cesium Radioisotopes)
SB  - IM
MH  - Brazil
MH  - Cells, Cultured
MH  - Cesium Radioisotopes/*adverse effects
MH  - Chromosome Aberrations/*genetics
MH  - Female
MH  - Follow-Up Studies
MH  - Gamma Rays/adverse effects
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphocytes/radiation effects
MH  - Male
MH  - *Radioactive Hazard Release
MH  - Radiometry
MH  - Retrospective Studies
MH  - Translocation, Genetic/radiation effects
EDAT- 1998/08/01 00:00
MHDA- 1998/08/01 00:01
CRDT- 1998/08/01 00:00
PHST- 1998/08/01 00:00 [pubmed]
PHST- 1998/08/01 00:01 [medline]
PHST- 1998/08/01 00:00 [entrez]
AID - S0027-5107(98)00021-9 [pii]
AID - 10.1016/s0027-5107(98)00021-9 [doi]
PST - ppublish
SO  - Mutat Res. 1998 May 25;400(1-2):299-312. doi: 10.1016/s0027-5107(98)00021-9.