PMID- 9687350
OWN - NLM
STAT- MEDLINE
DCOM- 19981021
LR  - 20190921
IS  - 0959-4388 (Print)
IS  - 0959-4388 (Linking)
VI  - 8
IP  - 3
DP  - 1998 Jun
TI  - Signals mediating ion channel clustering at the neuromuscular junction.
PG  - 357-63
AB  - High densities of acetylcholine receptors and sodium channels in the crests and 
      troughs of the postsynaptic folds, respectively, ensure reliable neuromuscular 
      signalling. Clustering of both ion channels is mediated by agrin. In the case of 
      acetylcholine receptors, agrin activates the tyrosine kinase receptor 
      muscle-specific kinase (MuSK), initiating a process requiring rapsyn and possibly 
      also receptor phosphorylation. In many respects, the interactions between agrin 
      and MuSK and their downstream effectors are atypical of conventional receptor 
      tyrosine kinase signalling systems. A new understanding of the structural 
      features of rapsyn involved in receptor clustering, as well as syntrophin's role 
      in sodium channel targeting, has recently been revealed. Perhaps the most 
      surprising result of the past year with regard to synaptogenesis is a negative 
      one--mice lacking both dystrophin and utrophin have nearly normal neuromuscular 
      junctions.
FAU - Colledge, M
AU  - Colledge M
AD  - Department of Physiology, University of North Carolina at Chapel Hill 27599-7545, 
      USA.
FAU - Froehner, S C
AU  - Froehner SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Curr Opin Neurobiol
JT  - Current opinion in neurobiology
JID - 9111376
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Neuromuscular Junction/*chemistry/physiology
MH  - Receptors, Cholinergic/chemistry/*physiology
MH  - Signal Transduction/*physiology
MH  - Sodium Channels/chemistry/*physiology
RF  - 70
EDAT- 1998/08/04 00:00
MHDA- 1998/08/04 00:01
CRDT- 1998/08/04 00:00
PHST- 1998/08/04 00:00 [pubmed]
PHST- 1998/08/04 00:01 [medline]
PHST- 1998/08/04 00:00 [entrez]
AID - S0959-4388(98)80061-5 [pii]
AID - 10.1016/s0959-4388(98)80061-5 [doi]
PST - ppublish
SO  - Curr Opin Neurobiol. 1998 Jun;8(3):357-63. doi: 10.1016/s0959-4388(98)80061-5.