PMID- 9688714
OWN - NLM
STAT- MEDLINE
DCOM- 19980903
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 85
IP  - 2
DP  - 1998 Aug
TI  - Metabolic and performance responses during endurance exercise after high-fat and 
      high-carbohydrate meals.
PG  - 418-24
AB  - We studied the effects of preexercise meal composition on metabolic and 
      performance-related variables during endurance exercise. Eight well-trained 
      cyclists (maximal oxygen uptake 65.0 to 83.5 ml . kg-1 . min-1) were studied on 
      three occasions after an overnight fast. They were given isoenergetic meals 
      containing carbohydrate (CHO), protein (P), and fat (F) in the following amounts 
      (g/70 kg body wt): high-carbohydrate meal, 215 CHO, 26 P, 3 F; high-fat meal, 50 
      CHO, 14 P, 80 F. On the third occasion subjects were studied after an overnight 
      fast. Four hours after consumption of the meal, subjects started exercise for 90 
      min at 70% of their maximal oxygen uptake, followed by a 10-km time trial. The 
      high-carbohydrate meal compared with the high-fat meal resulted in significant 
      decreases (P < 0.05) in blood glucose, plasma nonesterified fatty acids, plasma 
      glycerol, plasma chylomicron-triacylglycerol, and plasma 3-hydroxybutyrate 
      concentrations during exercise. This was accompanied by an increase in plasma 
      insulin (P < 0.01 vs. no meal), plasma epinephrine, and plasma growth hormone 
      concentrations (each P < 0.05 vs. either of the other conditions) during 
      exercise. Despite these large differences in substrate and hormone concentrations 
      in plasma, substrate oxidation during the 90-min exercise period was similar in 
      the three trials, and there were no differences in performance on the time trial. 
      These results suggest that, although the availability of fatty acids and other 
      substrates in plasma can be markedly altered by dietary means, the pattern of 
      substrate oxidation during endurance exercise is remarkably resistant to 
      alteration.
FAU - Whitley, H A
AU  - Whitley HA
AD  - Oxford Lipid Metabolism Group, Radcliffe Infirmary, Oxford OX2 6HE, UK.
FAU - Humphreys, S M
AU  - Humphreys SM
FAU - Campbell, I T
AU  - Campbell IT
FAU - Keegan, M A
AU  - Keegan MA
FAU - Jayanetti, T D
AU  - Jayanetti TD
FAU - Sperry, D A
AU  - Sperry DA
FAU - MacLaren, D P
AU  - MacLaren DP
FAU - Reilly, T
AU  - Reilly T
FAU - Frayn, K N
AU  - Frayn KN
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Hormones)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Bicycling/physiology
MH  - Blood Glucose/metabolism
MH  - Calorimetry, Indirect
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Energy Metabolism/drug effects
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Hormones/blood
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Oxygen Consumption/drug effects/physiology
MH  - Physical Endurance/drug effects/*physiology
EDAT- 1998/08/04 00:00
MHDA- 1998/08/04 00:01
CRDT- 1998/08/04 00:00
PHST- 1998/08/04 00:00 [pubmed]
PHST- 1998/08/04 00:01 [medline]
PHST- 1998/08/04 00:00 [entrez]
AID - 10.1152/jappl.1998.85.2.418 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1998 Aug;85(2):418-24. doi: 10.1152/jappl.1998.85.2.418.