PMID- 9689482
OWN - NLM
STAT- MEDLINE
DCOM- 19981029
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 796
IP  - 1-2
DP  - 1998 Jun 15
TI  - Dose-dependent effects of estradiol benzoate on 5-HT1A receptor agonist action.
PG  - 299-302
AB  - The lordosis-inhibiting effects of the 5-HT1A receptor agonist, 
      (+/-)8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were examined in 
      ovariectomized rats, hormone primed with 2.5, 7.5, or 25 micrograms estradiol 
      benzoate plus 500 micrograms progesterone. 8-OH-DPAT (50, 100 or 200 ng per 
      bilateral site) infused into the ventromedial nucleus of the hypothalamus (VMN), 
      inhibited lordosis behavior in all hormone-treated conditions. However, animals 
      primed with 2.5 micrograms estradiol benzoate were significantly more affected by 
      the infusion than rats primed with 7.5 or 25 micrograms of the hormone. These 
      findings strengthen prior speculations that 5-HT1A receptor function is modulated 
      by estrogen.
FAU - Jackson, A
AU  - Jackson A
AD  - Department of Biology, Texas Woman's University, Denton 76204, USA.
FAU - Uphouse, L
AU  - Uphouse L
LA  - eng
GR  - NIGMS 08256/GM/NIGMS NIH HHS/United States
GR  - R01 HD28419/HD/NICHD NIH HHS/United States
GR  - R01 MH51568/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Serotonin Receptor Agonists)
RN  - 4TI98Z838E (Estradiol)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Receptor Agonists/*pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Ventromedial Hypothalamic Nucleus/physiology
EDAT- 1998/08/05 00:00
MHDA- 1998/08/05 00:01
CRDT- 1998/08/05 00:00
PHST- 1998/08/05 00:00 [pubmed]
PHST- 1998/08/05 00:01 [medline]
PHST- 1998/08/05 00:00 [entrez]
AID - S0006-8993(98)00238-8 [pii]
AID - 10.1016/s0006-8993(98)00238-8 [doi]
PST - ppublish
SO  - Brain Res. 1998 Jun 15;796(1-2):299-302. doi: 10.1016/s0006-8993(98)00238-8.