PMID- 9689539
OWN - NLM
STAT- MEDLINE
DCOM- 19981015
LR  - 20181201
IS  - 0939-6411 (Print)
IS  - 0939-6411 (Linking)
VI  - 45
IP  - 1
DP  - 1998 Jan
TI  - Influence of processing on the stability and release properties of biodegradable 
      microspheres containing thioridazine hydrochloride.
PG  - 83-94
AB  - Biodegradable microspheres of poly(DL-lactic-co-glycolic acid) (PLGA) containing 
      thioridazine HCl were produced by four emulsion-solvent evaporation methods 
      including an O/W emulsion method, an O/O emulsion method, a W/O/W multiple 
      emulsion method, and a W/O/O/O multiple emulsion method. Gel permeation 
      chromatography was used to determine the molecular weight of the polymer before 
      and after processing. Resultant microspheres were either incubated in an oven at 
      40 degrees C, or stored in a desiccated chamber at 20 degrees C. Change in the 
      molecular weight of the polymer was monitored as a function of time. Premature 
      degradation of the polymer was evident in microspheres produced by the O/W 
      conventional solvent evaporation method. Thioridazine HCl catalyzed hydrolysis of 
      PLGA was evident in normalized molecular weight distribution plots of the O/W 
      microspheres. The in vitro release of thioridazine HCl from multiphase 
      microspheres produced by potentiometric dispersion was compared with the release 
      of drug from conventional microspheres prepared from the same polymer. Release of 
      thioridazine HCl from multiphase microspheres of the W/O/O/O type occurred by 
      diffusion during initial stages of drug release.
FAU - O'Donnell, P B
AU  - O'Donnell PB
AD  - Ligand Pharmaceuticals, San Diego, CA 92121, USA.
FAU - McGinity, J W
AU  - McGinity JW
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - N3D6TG58NI (Thioridazine)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - Biodegradation, Environmental
MH  - *Drug Compounding
MH  - Drug Delivery Systems/methods
MH  - *Drug Stability
MH  - Drug Storage
MH  - Lactic Acid/chemistry
MH  - Microspheres
MH  - Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry
MH  - Thioridazine/*administration & dosage/chemistry
MH  - Time Factors
EDAT- 1998/08/05 00:00
MHDA- 1998/08/05 00:01
CRDT- 1998/08/05 00:00
PHST- 1998/08/05 00:00 [pubmed]
PHST- 1998/08/05 00:01 [medline]
PHST- 1998/08/05 00:00 [entrez]
AID - S0939-6411(97)00126-4 [pii]
AID - 10.1016/S0939-6411(97)00126-4 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 1998 Jan;45(1):83-94. doi: 10.1016/S0939-6411(97)00126-4.