PMID- 9690786
OWN - NLM
STAT- MEDLINE
DCOM- 19981026
LR  - 20190822
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 36
IP  - 8
DP  - 1998 Aug
TI  - Cross-reactivity of an anti-okadaic acid antibody to dinophysistoxin-4 (DTX-4), 
      dinophysistoxin-5 (DTX-5), and an okadaic acid diol ester.
PG  - 1193-6
AB  - The cross-reactivity of the 6/50 monoclonal anti-okadaic acid antibody (mAb) to 
      the recently discovered diarrhetic shellfish poisoning (DSP) metabolites 
      dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid (OA) 
      diol ester was determined using a competitive indirect enzyme-linked 
      immunosorbent assay (ELISA). The reactivity of the antibody to these molecules 
      was compared to that with OA; the 6/50 mAb recognized all of these DSP compounds 
      with equal sensitivity within the working range of the antibody (10-100 nM for 
      OA). This confirms the ability of the antibody to detect all DSP compounds when 
      used in analyses including ELISA and immunocytochemistry.
FAU - Lawrence, J E
AU  - Lawrence JE
AD  - Department of Oceanography, Dalhousie University, Halifax, NS, Canada.
FAU - Cembella, A D
AU  - Cembella AD
FAU - Ross, N W
AU  - Ross NW
FAU - Wright, J L
AU  - Wright JL
LA  - eng
PT  - Journal Article
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Marine Toxins)
RN  - 0 (dinophysistoxin 5)
RN  - 0 (okadaic acid diol ester)
RN  - 162795-98-4 (dinophysistoxin 4)
RN  - 1W21G5Q4N2 (Okadaic Acid)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology
MH  - Cross Reactions
MH  - Dinoflagellida/*chemistry
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Marine Toxins/chemistry/*immunology
MH  - Okadaic Acid/*analogs & derivatives/chemistry/*immunology
EDAT- 1998/08/05 00:00
MHDA- 1998/08/05 00:01
CRDT- 1998/08/05 00:00
PHST- 1998/08/05 00:00 [pubmed]
PHST- 1998/08/05 00:01 [medline]
PHST- 1998/08/05 00:00 [entrez]
AID - S0041010198000051 [pii]
AID - 10.1016/s0041-0101(98)00005-1 [doi]
PST - ppublish
SO  - Toxicon. 1998 Aug;36(8):1193-6. doi: 10.1016/s0041-0101(98)00005-1.