PMID- 9695306
OWN - NLM
STAT- MEDLINE
DCOM- 19980827
LR  - 20190914
IS  - 0374-5600 (Print)
IS  - 0374-5600 (Linking)
VI  - 40
IP  - 3
DP  - 1998 Jun
TI  - Five cases of thrombocytopenia induced by primary human herpesvirus 6 infection.
PG  - 278-81
AB  - Five patients suffering from exanthem subitum with thrombocytopenia were 
      confirmed as primary human herpesvirus 6 (HHV-6) infection by serological test. 
      All cases had thrombocytopenia during the acute phase of exanthem subitum. The 
      clinical features of these cases were benign, and all recovered without any 
      specific treatment. Moreover, 4 of the 5 cases showed a mild elevation of hepatic 
      transaminase during the same period, and other viral infections including 
      cytomegalovirus, Epstein-Barr virus, and human herpesvirus 7 were ruled out in 
      these patients. It was speculated that direct inhibition of platelet production 
      by the virus or cytokine induced by the virus-infected cells was the mechanism of 
      the thrombocytopenia induced by primary HHV-6 infection.
FAU - Yoshikawa, T
AU  - Yoshikawa T
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Aichi, 
      Japan.
FAU - Morooka, M
AU  - Morooka M
FAU - Suga, S
AU  - Suga S
FAU - Niinomi, Y
AU  - Niinomi Y
FAU - Kaneko, T
AU  - Kaneko T
FAU - Shinoda, K
AU  - Shinoda K
FAU - Muraki, Y
AU  - Muraki Y
FAU - Takahashi, K
AU  - Takahashi K
FAU - Sugaya, N
AU  - Sugaya N
FAU - Asano, Y
AU  - Asano Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Acta Paediatr Jpn
JT  - Acta paediatrica Japonica : Overseas edition
JID - 0370357
RN  - 0 (Biomarkers)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Acute Disease
MH  - Alanine Transaminase/blood
MH  - Aspartate Aminotransferases/blood
MH  - Biomarkers
MH  - Exanthema Subitum/*complications
MH  - Female
MH  - *Herpesvirus 6, Human/isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Purpura, Thrombocytopenic, Idiopathic/blood/physiopathology/*virology
EDAT- 1998/08/08 00:00
MHDA- 1998/08/08 00:01
CRDT- 1998/08/08 00:00
PHST- 1998/08/08 00:00 [pubmed]
PHST- 1998/08/08 00:01 [medline]
PHST- 1998/08/08 00:00 [entrez]
AID - 10.1111/j.1442-200x.1998.tb01928.x [doi]
PST - ppublish
SO  - Acta Paediatr Jpn. 1998 Jun;40(3):278-81. doi: 
      10.1111/j.1442-200x.1998.tb01928.x.