PMID- 9696877
OWN - NLM
STAT- MEDLINE
DCOM- 19980916
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 72
IP  - 9
DP  - 1998 Sep
TI  - Preactivation of B lymphocytes does not enhance mouse mammary tumor virus 
      infection.
PG  - 7688-91
AB  - We investigated whether mouse mammary tumor virus (MMTV) favors preactivated or 
      naive B cells as targets for efficient infection. We have demonstrated previously 
      that MMTV activates B cells upon infection. Here, we show that polyclonal 
      activation of B cells leads instead to lower infection levels and attenuated 
      superantigen-specific T-cell responses in vivo. This indicates that naive small 
      resting B cells are the major targets of MMTV infection and that the activation 
      induced by MMTV is sufficient to allow efficient infection.
FAU - Finke, D
AU  - Finke D
AD  - Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 
      1066 Epalinges, Switzerland.
FAU - Mortezavi, L
AU  - Mortezavi L
FAU - Acha-Orbea, H
AU  - Acha-Orbea H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/drug effects/immunology/*virology
MH  - DNA, Viral
MH  - Lymphocyte Activation
MH  - Mammary Tumor Virus, Mouse/genetics/*physiology
MH  - Mice
MH  - Mice, Inbred BALB C
PMC - PMC110044
EDAT- 1998/08/08 00:00
MHDA- 1998/08/08 00:01
CRDT- 1998/08/08 00:00
PHST- 1998/08/08 00:00 [pubmed]
PHST- 1998/08/08 00:01 [medline]
PHST- 1998/08/08 00:00 [entrez]
AID - 2015 [pii]
AID - 10.1128/JVI.72.9.7688-7691.1998 [doi]
PST - ppublish
SO  - J Virol. 1998 Sep;72(9):7688-91. doi: 10.1128/JVI.72.9.7688-7691.1998.