PMID- 9697735
OWN - NLM
STAT- MEDLINE
DCOM- 19980904
LR  - 20190512
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 178
IP  - 2
DP  - 1998 Aug
TI  - Endogenous interleukin-10 modulates proinflammatory response in Plasmodium 
      falciparum malaria.
PG  - 520-5
AB  - Tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 are 
      implicated in the pathogenesis of severe Plasmodium falciparum malaria. In this 
      study, the effect of IL-10 on their production by peripheral blood mononuclear 
      cells (PBMC) from acutely infected patients was examined. Exogenous IL-10 
      inhibited malarial antigen-induced cytokine production by reducing mRNA 
      accumulation. Maximal inhibition occurred when IL-10 was added in the first 2 h 
      of stimulation. Conversely, the addition of anti-IL-10 markedly enhanced 
      TNF-alpha, IL-1beta, and IL-6 production. The effect was significantly greater on 
      PBMC from patients with uncomplicated infection than PBMC from patients with 
      severe disease. Kinetics studies showed that TNF-alpha, IL-6, and IL-1beta were 
      produced within 2-4 h of stimulation, while IL-10 was first detectable after 8 h. 
      These findings suggest that IL-10 counter-regulates the proinflammatory response 
      to P. falciparum. Severe falciparum malaria may be associated with an inadequate 
      negative feedback response by IL-10.
FAU - Ho, M
AU  - Ho M
AD  - Department of Microbiology & Infectious Diseases, University of Calgary, Canada. 
      mho@acs.ucalgary.ca
FAU - Schollaardt, T
AU  - Schollaardt T
FAU - Snape, S
AU  - Snape S
FAU - Looareesuwan, S
AU  - Looareesuwan S
FAU - Suntharasamai, P
AU  - Suntharasamai P
FAU - White, N J
AU  - White NJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Protozoan)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Antigens, Protozoan/immunology
MH  - Cells, Cultured
MH  - Humans
MH  - Interleukin-1/biosynthesis
MH  - Interleukin-10/biosynthesis/*immunology/pharmacology
MH  - Interleukin-6/biosynthesis
MH  - Kinetics
MH  - Leukocytes, Mononuclear/immunology
MH  - Malaria, Falciparum/blood/*immunology
MH  - Plasmodium falciparum/*immunology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1998/08/11 00:00
MHDA- 1998/08/11 00:01
CRDT- 1998/08/11 00:00
PHST- 1998/08/11 00:00 [pubmed]
PHST- 1998/08/11 00:01 [medline]
PHST- 1998/08/11 00:00 [entrez]
AID - 10.1086/515640 [doi]
PST - ppublish
SO  - J Infect Dis. 1998 Aug;178(2):520-5. doi: 10.1086/515640.