PMID- 9697740 OWN - NLM STAT- MEDLINE DCOM- 19980904 LR - 20190512 IS - 0022-1899 (Print) IS - 0022-1899 (Linking) VI - 178 IP - 2 DP - 1998 Aug TI - Congenital infections with human herpesvirus 6. PG - 544-6 AB - Cord blood DNA was tested for the presence of human herpesvirus 6 (HHV-6) DNA by the polymerase chain reaction. Specific DNA could be detected in the specimens of 5 (1.6%) of 305 babies born to ostensibly healthy mothers, indicating that intrauterine infection had occurred. These transmissions would not have been detected by serologic methods, because no specific IgM antibody could be found in the fetal sera. These results indicate that, in addition to infections acquired in early childhood, congenital infections may account for the HHV-6 seropositivity in children. FAU - Adams, O AU - Adams O AD - Institut fur Medizinische Mikrobiologie und Virologie, Dusseldorf, Germany. adamso@uni-duesseldorf.de FAU - Krempe, C AU - Krempe C FAU - Kogler, G AU - Kogler G FAU - Wernet, P AU - Wernet P FAU - Scheid, A AU - Scheid A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 RN - 0 (Antibodies, Viral) RN - 0 (DNA, Viral) RN - 0 (Immunoglobulin G) SB - IM CIN - J Infect Dis. 1999 Apr;179(4):1046-7. PMID: 10068608 MH - Antibodies, Viral/blood MH - DNA, Viral MH - Female MH - Herpesviridae Infections/*congenital/immunology/transmission/virology MH - Herpesvirus 6, Human/genetics/immunology/*isolation & purification MH - Humans MH - Immunoglobulin G/blood MH - Infant, Newborn MH - Infectious Disease Transmission, Vertical MH - Polymerase Chain Reaction EDAT- 1998/08/11 00:00 MHDA- 1998/08/11 00:01 CRDT- 1998/08/11 00:00 PHST- 1998/08/11 00:00 [pubmed] PHST- 1998/08/11 00:01 [medline] PHST- 1998/08/11 00:00 [entrez] AID - 10.1086/517470 [doi] PST - ppublish SO - J Infect Dis. 1998 Aug;178(2):544-6. doi: 10.1086/517470.