PMID- 9697973
OWN - NLM
STAT- MEDLINE
DCOM- 19981029
LR  - 20190921
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 20
IP  - 4
DP  - 1998 Jul-Aug
TI  - Effects of gestational nicotine exposure on hippocampal morphology.
PG  - 465-73
AB  - Morphology of the dentate gyrus and Ammon's horn of the hippocampus was observed 
      postnatally in Wistar rats exposed to prenatal nicotine. Pregnant Wistar rats 
      were injected with nicotine (2.5 mg/kg/ day) from gestational day (GD) 6 to term 
      and pups were delivered at term normally. The brains of nicotine-exposed pups at 
      postnatal day (PND) 40 were dissected and processed for araldite embedding. 
      Semithin (0.5 microm) toluidine blue-stained sections of the dentate gyrus, CA3, 
      and CA1 regions of the hippocampus were studied for morphological details. 
      Morphometric analysis showed a significant reduction in the neuronal area of 
      nicotine-exposed brains in all three regions studied. Distal dendritic arbor was 
      significantly less and spine density was more in the granule cells, terminal and 
      basal dendrites of the pyramidal neurons of CA3 and CA1 regions of the 
      hippocampus in the experimental group. CA3 pyramidal neurons showed significantly 
      less apical dendritic thorny excrescence after gestational nicotine exposure. 
      Ultrastructurally the granule cells and the pyramidal neurons of the CA3 and CA1 
      regions showed increase in free ribosomes and dilatation of rough endoplasmic 
      reticulum (RER) and Golgi apparatus cisternae in the nicotine-treated group. The 
      morphological changes in the hippocampus following prenatal nicotine exposure, as 
      observed in the present study, may contribute to the behavioural abnormalities.
FAU - Roy, T S
AU  - Roy TS
AD  - Department of Anatomy, All India Institute of Medical Sciences, New Delhi. 
      tsroy@medinst.ernet.in
FAU - Sabherwal, U
AU  - Sabherwal U
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Dendrites/drug effects
MH  - Dentate Gyrus/drug effects
MH  - Female
MH  - Hippocampus/cytology/*drug effects
MH  - Neurons/*drug effects/ultrastructure
MH  - Nicotine/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Pyramidal Cells/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Weight Gain/drug effects
EDAT- 1998/08/11 00:00
MHDA- 1998/08/11 00:01
CRDT- 1998/08/11 00:00
PHST- 1998/08/11 00:00 [pubmed]
PHST- 1998/08/11 00:01 [medline]
PHST- 1998/08/11 00:00 [entrez]
AID - S0892-0362(97)00137-2 [pii]
AID - 10.1016/s0892-0362(97)00137-2 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1998 Jul-Aug;20(4):465-73. doi: 
      10.1016/s0892-0362(97)00137-2.