PMID- 9698499
OWN - NLM
STAT- MEDLINE
DCOM- 19980908
LR  - 20071114
IS  - 0018-506X (Print)
IS  - 0018-506X (Linking)
VI  - 33
IP  - 3
DP  - 1998 Jun
TI  - Co-localization of estrogen receptor and aromatase enzyme immunoreactivities in 
      adult musk shrew brain.
PG  - 151-62
AB  - Estrogens are produced by the aromatization of androgens. These steroids exert 
      their actions after binding to their receptors. Past studies have shown that 
      estrogen receptors (ER) and aromatase enzyme (AROM) reside in many of the same 
      brain regions. Few studies, however, have examined the neural co-localization of 
      these important components involved in estrogen-activated behaviors. In the 
      present study we examined the co-localization of ER and AROM immunoreactive (ir) 
      neurons in musk shrew (Suncus murinus) brains. Data were collected from a 
      representative section from three neural regions, the bed nucleus of the stria 
      terminalis (BNST), medial preoptic area (mPOA), and ventromedial nucleus of the 
      hypothalamus (VMN). Here we report a sex difference in the number of ER-ir 
      neurons from the analyzed section of the mPOA and BNST. Females have more ER-ir 
      neurons in the mPOA and males have more in the BNST. In the sections we examined, 
      males tended to have more aromatase containing neurons than females. Although 
      there were no significant differences in the numbers of double-labeled cells, the 
      VMN contains the greatest percentage of these cells in both males and females; 
      followed by the mPOA and the BNST. In addition, in the mPOA of both sexes, a 
      distinct nucleus of aromatase containing neurons which was devoid of ER 
      immunoreactivity was noted. Area measurements of the AROM-ir nucleus showed that 
      it was significantly larger in males than in females. Taken together, these data 
      suggest that there is not extensive cellular co-localization of estrogen 
      receptors and aromatase enzyme in the musk shrew brain. However, the presence of 
      other genomic forms of ER (membrane and/or ERbeta) in AROM containing neurons has 
      not been ruled out by this study. Thus, we hypothesize that estrogens produced in 
      brain affect behavior by binding to ER in neurons other than those that contain 
      aromatase enzyme.
CI  - Copyright 1998 Academic Press.
FAU - Veney, S L
AU  - Veney SL
AD  - Department of Biology, University of Virginia, Charlottesville, Virginia, 22903, 
      USA.
FAU - Rissman, E F
AU  - Rissman EF
LA  - eng
GR  - MH01349/MH/NIMH NIH HHS/United States
GR  - NS35429/NS/NINDS NIH HHS/United States
GR  - P30-HD28934/HD/NICHD NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Receptors, Estrogen)
RN  - EC 1.14.14.1 (Aromatase)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Aromatase/*analysis
MH  - Brain Chemistry/*physiology
MH  - Female
MH  - Male
MH  - Preoptic Area/chemistry/enzymology
MH  - Receptors, Estrogen/*analysis
MH  - Septal Nuclei/chemistry/enzymology
MH  - Sex Characteristics
MH  - Shrews/*physiology
MH  - Ventromedial Hypothalamic Nucleus/chemistry/enzymology
EDAT- 1998/08/12 00:00
MHDA- 1998/08/12 00:01
CRDT- 1998/08/12 00:00
PHST- 1998/08/12 00:00 [pubmed]
PHST- 1998/08/12 00:01 [medline]
PHST- 1998/08/12 00:00 [entrez]
AID - S0018-506X(98)91446-5 [pii]
AID - 10.1006/hbeh.1998.1446 [doi]
PST - ppublish
SO  - Horm Behav. 1998 Jun;33(3):151-62. doi: 10.1006/hbeh.1998.1446.